U.S. Route 15 (US 15) is a part of the U.S. Highway System that runs from Walterboro, South Carolina to New York-Pennsylvania border in Lawrenceville, Pennsylvania. In Virginia, the U.S. Highway runs 230.37 miles (370.74 km) from the North Carolina state line near Clarksville north to the Maryland state line at the Potomac River near Lucketts. US 15 is a major north–south highway through the Piedmont of Virginia, connecting Clarksville and Farmville in Southside Virginia with Culpeper, Warrenton, and Leesburg in Northern Virginia.