U.S. Route 33 (US 33) is a United States Numbered Highway running from near Elkhart, Indiana, to Richmond, Virginia. Within the state of Ohio, it is a predominantly southeast–northwest highway running from west of Willshire before crossing over into West Virginia via the Ravenswood Bridge over the Ohio River. The route runs through largely rural territory throughout most of the state's west-central, central, and southeastern regions, although it also passes through large portions of downtown Columbus.