USS S-5 (SS-110) was a "Government-type" S-class submarine of the United States Navy. Her keel was laid down on 4 December 1917 by the Portsmouth Navy Yard of Kittery, Maine. She was launched on 10 November 1919, sponsored by Mrs. Glenn S. Burrell, and commissioned on 6 March 1920 with Lieutenant Commander Charles M. "Savvy" Cooke, Jr., in command. She sank accidentally during full-power trials on 1 September 1920, but due to actions by her crew and the crews of other ships, no lives were lost. Refloated, she was lost when she sank again while under tow on 3 September 1920.