The Ultimate Nullifier is a device of immense power in Marvel Comics. The device made its first appearance in Fantastic Four volume 1, issue #50 (May 1966), in which Johnny Storm retrieves it from the home of Galactus—as directed by Uatu the Watcher—for the Fantastic Four to employ against the threat of Galactus himself. The Nullifier appears as a small, hand-held metallic device with no apparent functionality. When first introduced in 1966 it was described as the only known weapon in the universe capable of inspiring fear in Galactus.