The 1948 South Carolina United States House of Representatives elections were held on November 2, 1948 to select six Representatives for two-year terms from the state of South Carolina. Four incumbents were re-elected, but John J. Riley of the 2nd congressional district was defeated in the Democratic primary by Hugo S. Sims, Jr. The seat remained with the Democrats along with the open seat in the 3rd congressional district and the composition of the state delegation remained solely Democratic.