beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGGST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 positionDefective ST3GAL3 does not transfer SA to keratanST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG30bcdbf285d187ee6b586ac1c619a8254193286b59f224dab1558c29d0ec45c8ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)7f7b49e6d53d8663a3ab06402ce0a957ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycansSialylation of Pre-NOTCHThe keratan chain can be capped by N-acetylneuraminic acid
annotatedSource
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
definition
Catalysis of the reaction: CMP ...... etyl-alpha-D-galactosaminyl-R.
database_cross_reference
EC:2.4.99.4
MetaCyc:2.4.99.4-RXN
RHEA:21616
Reactome:R-HSA-1022129
Reactome:R-HSA-1912378
Reactome:R-HSA-2046285
Reactome:R-HSA-3656258
Reactome:R-HSA-4084984
Reactome:R-HSA-9603987
Reactome:R-HSA-9605600
has_obo_namespace
molecular_function
has_related_synonym
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity
CMP-N-acetylneuraminate:beta-D ...... euraminyl-transferase activity
id
GO:0003836
type
label
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity