hydroxymethylbilane synthase activity
Note that this function was formerly EC:4.3.1.8.
20a0f12e24614eec3d5cc50a5f5fb41632133fb65a93bed8aa08a04e8bfff7db382c067254a31c348066216c2ddd02953b20414933214658fbf08a505ef580a74c555d6dcf6e523e177e881cb80f628962059c37d04499518c73e18cee75b78e66121333d6e3b8b13572cb18dca3ed4a6f76d532ce83c0958dda978196c2c8374 PBGs bind to form HMBb14434d23fe19d0059f28ec1fb9f24f5bc9762d4dce59a05b45c16cafee8e459c3442214290d28b7ceae4aa233780d61f573ae2b65a3d6eead7d63f5a57bf595
annotatedSource
hydroxymethylbilane synthase activity
Note that this function was formerly EC:4.3.1.8.
definition
Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
database_cross_reference
EC:2.5.1.61
KEGG_REACTION:R00084
MetaCyc:OHMETHYLBILANESYN-RXN
RHEA:13185
Reactome:R-HSA-189406
has_narrow_synonym
uroporphyrinogen I synthase activity
uroporphyrinogen I synthetase activity
has_obo_namespace
molecular_function
has_related_synonym
(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity
(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
HMB-synthase activity
porphobilinogen ammonia-lyase (polymerizing)
porphobilinogen deaminase activity
porphobilinogen:(4-[2-carboxye ...... ethyltransferase (hydrolysing)
pre-uroporphyrinogen synthase activity
uroporphyrinogen synthase activity
uroporphyrinogen synthetase activity
id
GO:0004418
type
comment
Note that this function was formerly EC:4.3.1.8.
label
hydroxymethylbilane synthase activity