01c04a6c7fb1cdef4162428bf03e1d6c0f2d6648af646f88dd0f2496eba34f6e197333a6e4009f6b8860541750ccebb82ceae217462499702e5ceb33950c660dCYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D3e90b0311e28ab60e67461f02fce9b07490fe7cdfcadce0aa37185a4265c4e527d2f2a2efb76db50d3a288da2b8cf6a89f01eec8e0805af2fdbfa209d62b399db078325e100e38efc3982f1e4cd8c52bDefective CYP27B1 does not hydroxylate CDL
annotatedSource
definition
Catalysis of the reaction: cal ...... calcitriol + H(2)O + NADP(+).
database_cross_reference
EC:1.14.15.18
KEGG_REACTION:R03610
MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN
RHEA:20573
Reactome:R-HSA-209868
Reactome:R-HSA-5602186
has_exact_synonym
25-hydroxy vitamin D3 1-alpha-hydroxylase activity
25-hydroxycholecalciferol 1-hydroxylase activity
calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
has_narrow_synonym
cytochrome P450 CYP27B
has_obo_namespace
molecular_function
has_related_synonym
1-hydroxylase-25-hydroxyvitamin D3 activity
25-OHD-1 alpha-hydroxylase activity
25-hydroxy D3-1alpha-hydroxylase activity
25-hydroxycholecalciferol 1-monooxygenase activity
25-hydroxycholecalciferol 1alpha-hydroxylase activity
25-hydroxycholecalciferol-1-hydroxylase activity
25-hydroxyvitamin D-1 alpha hydroxylase activity
25-hydroxyvitamin D3 1alpha-hydroxylase activity
id
GO:0004498
type
label
calcidiol 1-monooxygenase activity