about
P688
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domainLRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityBiochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimersKinase activity of mutant LRRK2 mediates neuronal toxicityLeucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi exportARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanismFunctional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyRAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease riskLocalization of LRRK2 to membranous and vesicular structures in mammalian brainLRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activityUnbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson diseaseLeucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like proteinStructural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contactsLoss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged micePhosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's diseaseGene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse modelsLeucine-rich repeat kinase 2 associates with lipid raftsLeucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation.Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes
P921
Q21144926-5DF7C83A-8A42-4CD1-9536-A9F31B3D03F1Q24293453-ECD689F2-CA29-49A3-B7E6-022D0CD21131Q24296778-272ABF80-EB9D-45DC-A553-B7238D545496Q24296968-23212B47-6D48-4858-8F2C-6374C448F627Q24298093-341AD14A-4B3A-40DB-8C0A-57E8FBCE037DQ24303603-273DDEC1-B3DD-4E52-9291-D6159C1BF474Q24303851-86D27A74-C645-48C2-9F13-DFA103B2F219Q24305448-39AF24E9-36AF-43C6-8756-22E7F9D5ED32Q24307742-8B521DA4-95D4-4FB9-ADE5-2F23DFDC0EE8Q24309509-12A8606C-29BE-4F1A-B2B2-7D4380F564F2Q24310218-A2060E58-8686-404F-BBB8-5297DC468F69Q24315688-060D1023-6D66-4D29-ADBC-E360BA322D03Q24318643-05BB2CC0-81C7-4754-A781-5B2C45B2B915Q24323196-9D35F4E0-BC53-495C-A7E7-34BEE0330DBDQ24336432-57828FA4-93EE-49D8-9271-01271536E839Q24336889-C1C6B6CE-6D7D-4573-A203-87D4406917E2Q28116245-188A268F-E54A-45F3-B3DC-860F2A91A931Q28507051-A8AFB9E5-2F49-4AF0-8C21-651E3242E2C2Q28586694-637EF105-B545-4DBA-835E-E2D57C62D14CQ28589606-9EE4A4AA-78D2-462B-9875-762AB7A33B68Q28591286-EABA434E-8721-46D6-BCE6-AD304B957FC7Q41791628-8FBDB121-BE15-4935-BCCA-A8BAEE41E752Q47909797-88C0CF8A-33F4-4237-9038-E4B6BCCE67C2Q52355227-4A39D6E5-E425-4388-A201-E2D3289F7441Q64069540-464F0468-BFF6-4EBE-8428-60A63F1D0E5E
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Leucine-rich repeat kinase 2
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
Leucine-rich repeat kinase 2
@en
Leucine-rich repeat kinase 2
@nl
type
label
Leucine-rich repeat kinase 2
@en
Leucine-rich repeat kinase 2
@nl
altLabel
Lrrk2
@en
leucine-rich repeat serine/threonine-protein kinase 2
@en
uniprot:Q5S006
@en
prefLabel
Leucine-rich repeat kinase 2
@en
Leucine-rich repeat kinase 2
@nl
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XP_006521340
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ENSMUSP00000052584