Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein CConjectures and refutations on the mode of action of heparins. The limited importance of anti-factor xa activity as a pharmaceutical mechanism and a yardstick for therapy.Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.The mode of action of heparins in vitro and in vivo.Mode of action of heparin and related drugs.Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and "clinical restenosis".Mode of action of enoxaparin in plasma.Mode of action of unfractionated and low molecular weight heparins on the generation of thrombin in plasma.The ex vivo correlate of the antithrombotic action of heparin.Purification and properties of the phenprocoumon-induced decarboxyfactor X from bovine plasma. A comparison to normal factor X.Activation of decarboxyfactor X by a protein from Russell's viper venom. Purification and partial characterization of activated decarboxyfactor X.Fibrin-dependent platelet procoagulant activity requires GPIb receptors and von Willebrand factor.Isolation and partial characterization of a vitamin K-dependent carboxylase from bovine aortae.Regulation of platelet factor Va-dependent thrombin generation by activated protein C at the surface of collagen-adherent platelets.The synthesis of prothrombin from its precursor protein.The inhibition of blood coagulation by heparins of different molecular weight is caused by a common functional motif--the C-domain.The ionic contrast medium ioxaglate interferes with thrombin-mediated feedback activation of factor V, factor VIII and platelets.Vitamin K-dependent carboxylase: the carboxylation of exogenous substrates in different systems.Importance of factor-IX-dependent prothrombinase formation--the Josso pathway--in clotting plasma.Low molecular weight heparin inhibits plasma thrombin generation via direct targeting of factor IXa: a rebuttal.Fixed dosage of low-molecular-weight heparins causes large individual variation in coagulability, only partly correlated to body weight.Studies on blood coagulation factor V. V. Changes of molecular weight accompanying activation of factor V by thrombin and the procoagulant protein of Russell's viper venom.Laboratory monitoring of low-molecular-weight heparin therapy--part II. Monitoring LMWH therapy? For the moment a non-question.Determination of the levels of unfractionated and low-molecular-weight heparins in plasma: their effect on thrombin-mediated feedback reactions in vivo. Preliminary results after subcutaneous injection.Demonstration of three anomalous plasma proteins induced by a vitamin K antagonist.The love of the artist for his model of thrombin generation.Mathematical and biological models of blood coagulation. A rebuttal.The consumption of antithrombin III during coagulation, its consequences for the calculation of prothrombinase activity and the standardisation of heparin activity.A method for measuring activated factor VIII in plasma.A computer assisted method to obtain the prothrombin activation velocity in whole plasma independent of thrombin decay processes.Studies on blood coagulation factor V. VI. The inactivation of factor V and prothrombinase.The activity of unfractionated heparin and low molecular weight heparins in rabbit plasma--the need for using absolute anti-factor Xa and antithrombin activities.Low molecular weight heparin-catalyzed inactivation of factor Xa and thrombin by antithrombin III--effect of platelet factor 4.The relative importance of the factors II, VII, IX and X for the prothrombinase activity in plasma of orally anticoagulated patients.Thrombin generation in plasma: its assessment via the endogenous thrombin potential.The thrombogram: monitoring thrombin generation in platelet-rich plasma.Purification and partial characterization of draculin, the anticoagulant factor present in the saliva of vampire bats (Desmodus rotundus).
P50
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P50
subject
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Dutch university teacher
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Dutch university teacher
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Dutch university teacher
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Hochschullehrer
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Hollandi ülikooli õppejõud
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Nederlands hoogleraar
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Universiteit onderwyser
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academydd
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dosen
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profesor universitar holandez
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Coen Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Coen Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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C. Hemker
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Coen Hemker
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H. C. Hemke
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H. C. Hemker
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H.C. Hemker
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H.C. Hemker
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Hendrik Coenraad Hemker
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Coen Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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Hendrik Coenraad Hemker
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P108
P735
P1006
P1015
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P244
P268
P269
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P1015
P106
P1207
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