NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas
about
New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovationNew genes contribute to genetic and phenotypic novelties in human evolutionThe Recent De Novo Origin of Protein C-Termini.MYCNOS functions as an antisense RNA regulating MYCNOrigins of De Novo Genes in Human and Chimpanzee.Proteogenomic analysis reveals alternative splicing and translation as part of the abscisic acid response in Arabidopsis seedlings.De Novo Genes Arise at a Slow but Steady Rate along the Primate Lineage and Have Been Subject to Incomplete Lineage Sorting.Neuroblastoma models for insights into tumorigenesis and new therapies.Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma.Sendai virus-mediated expression of reprogramming factors promotes plasticity of human neuroblastoma cells.Functional interplay between MYCN, NCYM, and OCT4 promotes aggressiveness of human neuroblastomas.Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1-42 induced neurotoxicity and memory impairment.Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63.Delineation of the frequency and boundary of chromosomal copy number variations in paediatric neuroblastoma.Splicing regulation by long noncoding RNAs.Prognostic significance of MYCN gene amplification and protein expression in primary brain tumors: Astrocytoma and meningioma.The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells.Methylation of DNA and chromatin as a mechanism of oncogenesis and therapeutic target in neuroblastoma.
P2860
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P2860
NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas
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2014 nî lūn-bûn
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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2014 թվականի հունվարին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@ast
NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@en
NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@en-gb
NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@nl
type
label
NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@ast
NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@en
NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@en-gb
NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@nl
altLabel
NCYM, a Cis-Antisense Gene of ...... f MYCN in Human Neuroblastomas
@en
prefLabel
NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@ast
NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@en
NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@en-gb
NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@nl
P2093
P2860
P921
P3181
P1433
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NCYM, a Cis-antisense gene of ...... f MYCN in human neuroblastomas
@en
P2093
Akira Nakagawara
Atsushi Takatori
Daisuke Matsumoto
Hidetada Kawana
Jennifer Alagu
Makiko Itami
Mami Yamamoto
Mamoru Kato
Miki Ohira
S M Rafiqul Islam
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1003996
P407
P577
2014-01-01T00:00:00Z