Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity
about
Unwinding and rewinding: double faces of helicase?Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4The RecQ DNA helicases in DNA repairRecQ helicase translocates along single-stranded DNA with a moderate processivity and tight mechanochemical couplingHuman premature aging, DNA repair and RecQ helicasesCrystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA binding activityStructure of the human RECQ1 helicase reveals a putative strand-separation pinAn essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.Human RECQL1 participates in telomere maintenanceDistinct roles of RECQ1 in the maintenance of genomic stability.Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaksHuman RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structuresRECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress.Polarity and bypass of DNA heterology during branch migration of Holliday junctions by human RAD54, BLM, and RECQ1 proteinsHuman RecQ helicases in DNA repair, recombination, and replication.Intrinsic ssDNA annealing activity in the C-terminal region of WRN.Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structuresEnhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome proteinRECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures.Unique and important consequences of RECQ1 deficiency in mammalian cells.RECQ1 possesses DNA branch migration activity.RECQL: a new breast cancer susceptibility gene.Rising from the RecQ-age: the role of human RecQ helicases in genome maintenanceThe BLM dissolvasome in DNA replication and repair.Visualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates.Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma.Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.RecQ helicases: multiple structures for multiple functions?Rad54, the motor of homologous recombination.Probing Genome Maintenance Functions of human RECQ1.Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases.Rad51 protein stimulates the branch migration activity of Rad54 protein.Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains.Multimerization domains are associated with apparent strand exchange activity in BLM and WRN DNA helicases.A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domainThe Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.
P2860
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P2860
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Different quaternary structure ...... th its dual enzymatic activity
@ast
Different quaternary structure ...... th its dual enzymatic activity
@en
Different quaternary structure ...... th its dual enzymatic activity
@en-gb
Different quaternary structure ...... th its dual enzymatic activity
@nl
type
label
Different quaternary structure ...... th its dual enzymatic activity
@ast
Different quaternary structure ...... th its dual enzymatic activity
@en
Different quaternary structure ...... th its dual enzymatic activity
@en-gb
Different quaternary structure ...... th its dual enzymatic activity
@nl
altLabel
Different Quaternary Structure ...... th Its Dual Enzymatic Activity
@en
prefLabel
Different quaternary structure ...... th its dual enzymatic activity
@ast
Different quaternary structure ...... th its dual enzymatic activity
@en
Different quaternary structure ...... th its dual enzymatic activity
@en-gb
Different quaternary structure ...... th its dual enzymatic activity
@nl
P2093
P2860
P50
P1433
P1476
Different quaternary structure ...... th its dual enzymatic activity
@en
P2093
Alessandro Vindigni
Benedetta Niccolini
Fabienne Beuron
Laura Muzzolini
Mathieu Rappas
Venkateswarlu Popuri
P2860
P356
10.1371/JOURNAL.PBIO.0050020
P407
P577
2007-02-01T00:00:00Z