Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL
about
The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cellsPim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylationPIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancersEnhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinaseTargeting the Pim kinases in multiple myelomaTricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cellsCell-permeable Carboxyl-terminal p27Kip1 Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 KinaseThe PIM kinases in hematological cancers14-3-3 zeta as novel molecular target for cancer therapyPim kinase inhibitors: a survey of the patent literatureSmall molecule inhibitors of PIM1 kinase: July 2009 to February 2013 patent updateFragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitorsEvidence that the Pim1 kinase gene is a direct target of HOXA9Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cellsPim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasionOver-expression of 14-3-3zeta is an early event in oral cancer.CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death.Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggsSynthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.Rational Redesign of a Functional Protein Kinase-Substrate Interaction.Pim-1 kinase protects mitochondrial integrity in cardiomyocytes.Ectopic over-expression of oncogene Pim-2 induce malignant transformation of nontumorous human liver cell line L02Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genesActivation of cell cycle arrest and apoptosis by the proto-oncogene Pim-2.Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair.Phosphorylation of transglutaminase 2 (TG2) at serine-216 has a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTENPim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair.Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth.The Pim protein kinases regulate energy metabolism and cell growthThe oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.BTEB2 prevents neuronal apoptosis via promoting bad phosphorylation in rat intracerebral hemorrhage modelPIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancerInitial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program.PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cellsCharacterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.Combination of Pim kinase inhibitors and Bcl-2 antagonists in chronic lymphocytic leukemia cellsPIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.
P2860
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P2860
Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL
description
2006 nî lūn-bûn
@nan
2006 թուականին հրատարակուած գիտական յօդուած
@hyw
2006 թվականին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@ast
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@en
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@en-gb
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@nl
type
label
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@ast
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@en
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@en-gb
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@nl
prefLabel
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@ast
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@en
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@en-gb
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@nl
P2093
P2860
P3181
P356
P1433
P1476
Pim kinases phosphorylate mult ...... g and dissociation from Bcl-XL
@en
P2093
C James Hastie
David G Campbell
Hilary McLauchlan
Rachel Toth
P2860
P2888
P3181
P356
10.1186/1471-2121-7-1
P407
P577
2006-01-10T00:00:00Z
P5875
P6179
1022909103