about
P688
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathwayGlutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunityThe N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity.Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseasesInnate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.Mitotic progression following DNA damage enables pattern recognition within micronuclei.Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.Nuclear cGAS suppresses DNA repair and promotes tumorigenesisStructure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune SurveillancePhosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA
P921
Q24306635-18DE0C38-CB9E-467A-9BF1-5ABEC7F1E5BAQ28504520-836040C3-8E81-49BA-AE76-710B294BB9F6Q29871106-3FBDD9DD-9BBC-48C8-9F2A-F070C6341575Q29871114-49F24839-C2B8-4F2A-8107-C2E0E70C57B3Q34362864-17D83A91-C277-4A5B-8C5A-49F857A5D1C9Q34374085-13D9587B-4C52-4584-97C0-377C2E6993BCQ36207338-8F465336-F7AF-420C-825A-D83456E9FA57Q40036388-EC124E73-4150-445D-96D3-ED8C05A89B31Q40036392-00D6B00A-B536-45DF-859A-0673760E24ADQ42367804-57376628-39C2-4092-9DA3-E8014AECD184Q57793642-FEF9861D-E03C-4B35-9DEF-A114E64A23EAQ90210829-8B48CF5A-5D17-49AB-857D-30241110CCB4Q92083784-738D8030-4075-4385-9460-A297F750B8EC
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Cyclic GMP-AMP synthase
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Cyclic GMP-AMP synthase
@en
Cyclic GMP-AMP synthase
@nl
type
label
Cyclic GMP-AMP synthase
@en
Cyclic GMP-AMP synthase
@nl
altLabel
2'3'-cGAMP synthase
@en
Cgas
@en
Mab-21 domain containing 1
@en
Mb21d1
@en
cGAMP synthase
@en
cyclic GMP-AMP synthase
@en
mab-21 domain-containing protein 1
@en
prefLabel
Cyclic GMP-AMP synthase
@en
Cyclic GMP-AMP synthase
@nl
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ENSMUSP00000034898
ENSMUSP00000063331
ENSMUSP00000114277