Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases
about
Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genesExcision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteinsDeficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx proteinTrex1 prevents cell-intrinsic initiation of autoimmunityBiochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta.A 4-year-old Amish boy with weakness, arthritis, rash, verbal delay, and failure to thriveTranscriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptationRPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNAThe crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partneringStructure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW DomainsDefects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune diseaseRecognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonucleaseThe Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δThe human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysisTLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathwaysMouse models for Aicardi-Goutières syndrome provide clues to the molecular pathogenesis of systemic autoimmunityAicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase.The migraine-stroke connection: A genetic perspective.A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA.Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome.Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletionNew roles for the major human 3'-5' exonuclease TREX1 in human disease.The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleasesEvidence for extrinsic exonucleolytic proofreading.The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.A transcriptome analysis by lasso penalized Cox regression for pancreatic cancer survival.Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.Intrinsic self-DNA triggers inflammatory disease dependent on STING.Evolution of a tumor-like lesion in cerebroretinal vasculopathy and TREX1 mutation.Simple and convenient G-quadruplex-based turn-on fluorescence assay for 3' → 5' exonuclease activity.The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response.Gaining a foothold: how HIV avoids innate immune recognition.Functional consequences of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome.Restriction genes for retroviruses influence the risk of multiple sclerosis.SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation.Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.
P2860
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P248
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P2860
Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Identification and expression ...... mammalian 3'-->5' exonucleases
@ast
Identification and expression ...... mammalian 3'-->5' exonucleases
@en
Identification and expression ...... mammalian 3'-->5' exonucleases
@en-gb
Identification and expression ...... mammalian 3'-->5' exonucleases
@nl
type
label
Identification and expression ...... mammalian 3'-->5' exonucleases
@ast
Identification and expression ...... mammalian 3'-->5' exonucleases
@en
Identification and expression ...... mammalian 3'-->5' exonucleases
@en-gb
Identification and expression ...... mammalian 3'-->5' exonucleases
@nl
prefLabel
Identification and expression ...... mammalian 3'-->5' exonucleases
@ast
Identification and expression ...... mammalian 3'-->5' exonucleases
@en
Identification and expression ...... mammalian 3'-->5' exonucleases
@en-gb
Identification and expression ...... mammalian 3'-->5' exonucleases
@nl
P2860
P3181
P356
P1476
Identification and expression ...... mammalian 3'-->5' exonucleases
@en
P2093
F W Perrino
P2860
P304
P3181
P356
10.1074/JBC.274.28.19655
P407
P577
1999-07-09T00:00:00Z