Identification of the Nef-associated kinase as p21-activated kinase 2
about
Systematic identification of regulatory proteins critical for T-cell activationStructure--function relationships in HIV-1 Nef.Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathwaysHIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activationConformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assemblyCdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation.Lentivirus Nef specifically activates Pak2.A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.The HIV-1 Nef protein as a target for antiretroviral therapy.Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-thetaDesign and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation."UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infectionGenetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolatesHuman immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions.Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1.MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1.Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIXReconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex.Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylationNef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.Trans-cellular introduction of HIV-1 protein Nef induces pathogenic response in Caenorhabditis elegans.Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptorsHuman immunodeficiency virus-1 (HIV-1)-mediated apoptosis: new therapeutic targets.Emerging functions of p21-activated kinases in human cancer cells.PAK1 as a therapeutic target.Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef.CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variableAssociation with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways.HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein.Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles.Viral modulation of T-cell receptor signalingHIV-1 Nef: at the crossroadsAlphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases.A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef functionHuman N-myristoyltransferases form stable complexes with lentiviral nef and other viral and cellular substrate proteins.Protein intrinsic disorder as a flexible armor and a weapon of HIV-1.Herbal therapeutics that block the oncogenic kinase PAK1: a practical approach towards PAK1-dependent diseases and longevity.The activity of Nef on HIV-1 infectivityNef as a Proliferative Factor for Kidney Epithelial Cells in HIV-Associated Nephropathy.
P2860
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P2860
Identification of the Nef-associated kinase as p21-activated kinase 2
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Identification of the Nef-associated kinase as p21-activated kinase 2
@ast
Identification of the Nef-associated kinase as p21-activated kinase 2
@en
Identification of the Nef-associated kinase as p21-activated kinase 2
@en-gb
Identification of the Nef-associated kinase as p21-activated kinase 2
@nl
type
label
Identification of the Nef-associated kinase as p21-activated kinase 2
@ast
Identification of the Nef-associated kinase as p21-activated kinase 2
@en
Identification of the Nef-associated kinase as p21-activated kinase 2
@en-gb
Identification of the Nef-associated kinase as p21-activated kinase 2
@nl
prefLabel
Identification of the Nef-associated kinase as p21-activated kinase 2
@ast
Identification of the Nef-associated kinase as p21-activated kinase 2
@en
Identification of the Nef-associated kinase as p21-activated kinase 2
@en-gb
Identification of the Nef-associated kinase as p21-activated kinase 2
@nl
P2093
P1433
P1476
Identification of the Nef-associated kinase as p21-activated kinase 2
@en
P2093
P304
P356
10.1016/S0960-9822(00)80086-X
P407
P577
1999-12-02T00:00:00Z