WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog
about
MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysisThe subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activityA novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like networkWilliams syndrome deficits in visual spatial processing linked to GTF2IRD1 and GTF2I on chromosome 7q11.23The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXRA glucose-responsive transcription factor that regulates carbohydrate metabolism in the liverAdenosine-containing molecules amplify glucose signaling and enhance txnip expression.Glucose controls nuclear accumulation, promoter binding, and transcriptional activity of the MondoA-Mlx heterodimer.Heterozygous disruption of the TATA-binding protein gene in DT40 cells causes reduced cdc25B phosphatase expression and delayed mitosis.A novel N-terminal domain may dictate the glucose response of Mondo proteins.Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP).Evolution of the Max and Mlx networks in animals.Contrasting Patterns in the Evolution of Vertebrate MLX Interacting Protein (MLXIP) and MLX Interacting Protein-Like (MLXIPL) Genes.The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humansA C. elegans Myc-like network cooperates with semaphorin and Wnt signaling pathways to control cell migration.Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from Mondo conserved regions and essential trans-acting factor 14-3-3Integration of ChREBP-Mediated Glucose Sensing into Whole Body Metabolism.Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes.Metabolic abnormalities in Williams-Beuren syndrome.A postmortem stereological study of the amygdala in Williams syndrome.Recent insights into the role of ChREBP in intestinal fructose absorption and metabolismmiR-1322 regulates ChREBP expression via binding a 3'-UTR variant (rs1051943)
P2860
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P2860
WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog
description
2000 nî lūn-bûn
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WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@ast
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@en
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@en-gb
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@nl
type
label
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@ast
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@en
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@en-gb
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@nl
prefLabel
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@ast
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@en
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@en-gb
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@nl
P2093
P356
P1476
WBSCR14, a putative transcript ...... an gene and the mouse ortholog
@en
P2093
P2888
P304
P356
10.1038/SJ.EJHG.5200435
P407
P577
2000-03-01T00:00:00Z
P5875
P6179
1049577044