IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7
about
Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationThe evolution of the Sin1 gene product, a little known protein implicated in stress responses and type I interferon signaling in vertebratesResistance to IFN-alpha-induced apoptosis is linked to a loss of STAT2IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis.Epigenetic silencing of IRF7 and/or IRF5 in lung cancer cells leads to increased sensitivity to oncolytic virusesFrequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer.Biology of EWS/ETS fusions in Ewing's family tumors.Targeting CD13 (aminopeptidase-N) in turn downregulates ADAM17 by internalization in acute myeloid leukaemia cells.Regulation of hepatocyte fate by interferon-γ.Interferon α/β Enhances the Cytotoxic Response of MEK Inhibition in Melanoma.The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer.Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation.Expression and in vitro cleavage activity of anti-caspase-7 hammerhead ribozymes.Augmentation of effects of interferon-stimulated genes by reversal of epigenetic silencing: potential application to melanoma.Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity.Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cellsCD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis.IFN-β induces greater antiproliferative and proapoptotic effects and increased p53 signaling compared with IFN-α in PBMCs of Adult T-cell Leukemia/Lymphoma patientsFunction and mechanism by which interferon regulatory factor-1 inhibits oncogenesis.Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B.2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells.Role of protein kinase C isoforms in the regulation of interleukin-13-induced 15-lipoxygenase gene expression in human monocytes.Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells.The oncolytic activity of Newcastle disease virus in clear cell renal carcinoma cells in normoxic and hypoxic conditions: the interplay between von Hippel-Lindau and interferon-β signaling.Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated serine 727 phosphorylation of Stat1 and Stat3.Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS.TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma.Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma.Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway.gamma-Glutamyl transpeptidase expression in Ewing's sarcoma cells: up-regulation by interferons.Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen-activated protein kinase/STAT1/reactive oxygen species pathway.Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis.Strong inhibition of Ewing tumor xenograft growth by combination of human interferon-alpha or interferon-beta with ifosfamide.Effect of fibroblast growth factor-1 on the expression of early growth response-1 in human periodontal ligament cells.Altered phenotype of dextran sulfate sodium colitis in interferon regulatory factor-1 knock-out mice.XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesisUSP18 establishes the transcriptional and anti-proliferative interferon α/β differential
P2860
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P2860
IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7
description
2000 nî lūn-bûn
@nan
2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@ast
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@en
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@en-gb
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@nl
type
label
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@ast
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@en
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@en-gb
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@nl
prefLabel
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@ast
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@en
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@en-gb
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@nl
P2093
P2860
P921
P356
P1433
P1476
IFN-beta induces serine phosph ...... -1 and activation of caspase-7
@en
P2093
J Wietzerbin
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203670
P407
P577
2000-07-13T00:00:00Z
P5875
P6179
1033280951