The molecular mechanism of lead inhibition of human porphobilinogen synthase
about
ALAD porphyria is a conformational diseaseRhodobacter capsulatus porphobilinogen synthase, a high activity metal ion independent hexamerProtein design: toward functional metalloenzymesSpecies-specific inhibition of porphobilinogen synthase by 4-oxosebacic acidControl of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthasePb 2+ as Modulator of Protein–Membrane InteractionsAssociation between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjectsDelta-aminolevulinic acid dehydratase polymorphism and the relation between low level lead exposure and the Mini-Mental Status Examination in older men: the Normative Aging StudyA framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologsEnvironmental contaminants perturb fragile protein assemblies and inhibit normal protein function.Case-only gene-environment interaction between ALAD tagSNPs and occupational lead exposure in prostate cancer.Substrate-induced interconversion of protein quaternary structure isoforms.Lead(II) complex formation with glutathione.The Content of the 14 Metals in Cancellous and Cortical Bone of the Hip Joint Affected by Osteoarthritis.From bortezomib to other inhibitors of the proteasome and beyond.Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach.Applications of Tripodal [S(3)] and [Se(3)] L(2)X Donor Ligands to Zinc, Cadmium and Mercury Chemistry: Organometallic and Bioinorganic Perspectives.Heterochromia in designed metallopeptides: geometry-selective binding of CdII in a de novo peptide.pH-dependent coordination of Pb2+ to metallothionein2: structures and insight into lead detoxificationInvolvement of ALAD-20S Proteasome Complexes in Ubiquitination and Acetylation of Proteasomal α2 Subunits.Proteome-wide analysis of nonsynonymous single-nucleotide variations in active sites of human proteins.Structural differences between Pb2+- and Ca2+-binding sites in proteins: implications with respect to toxicityStructural studies of substrate and product complexes of 5-aminolaevulinic acid dehydratase from humans, Escherichia coli and the hyperthermophile Pyrobaculum calidifontis.The Remarkable Character of Porphobilinogen Synthase.A structural basis for half-of-the-sites metal binding revealed in Drosophila melanogaster porphobilinogen synthase.Molecular docking studies of disubstituted diaryl diselenides as mammalian δ-aminolevulinic acid dehydratase enzyme inhibitors.ALAD binds to Pb2+Redox and metal-regulated oligomeric state for human porphobilinogen synthase activation.
P2860
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P2860
The molecular mechanism of lead inhibition of human porphobilinogen synthase
description
2001 nî lūn-bûn
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2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@ast
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@en
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@en-gb
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@nl
type
label
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@ast
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@en
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@en-gb
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@nl
prefLabel
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@ast
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@en
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@en-gb
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@nl
P2093
P2860
P356
P1476
The molecular mechanism of lead inhibition of human porphobilinogen synthase
@en
P2093
P2860
P304
P356
10.1074/JBC.M007663200
P407
P577
2001-01-01T00:00:00Z