Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin
about
Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathwayA conserved phosphatase cascade that regulates nuclear membrane biogenesisInsulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin.The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme.Mammalian phospholipase D physiological and pathological rolesRoles of phosphatidate phosphatase enzymes in lipid metabolismInsights into obesity and diabetes at the intersection of mouse and human geneticsGenetically modified mouse models for the study of nonalcoholic fatty liver diseaseLipins, lipinopathies, and the modulation of cellular lipid storage and signalingModulation of the transcriptional activity of peroxisome proliferator-activated receptor gamma by protein-protein interactions and post-translational modificationsNew advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseasesDeficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formationA role for phosphatidic acid in the formation of "supersized" lipid dropletsTissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formationPhosphorylation regulates the ubiquitin-independent degradation of yeast Pah1 phosphatidate phosphatase by the 20S proteasome.A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase.The Saccharomyces cerevisiae actin patch protein App1p is a phosphatidate phosphatase enzyme.Phosphorylation of Yeast Pah1 Phosphatidate Phosphatase by Casein Kinase II Regulates Its Function in Lipid MetabolismThe lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology.The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growthIntegral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulumYeast Nem1-Spo7 protein phosphatase activity on Pah1 phosphatidate phosphatase is specific for the Pho85-Pho80 protein kinase phosphorylation sites.Yeast lipin 1 orthologue pah1p regulates vacuole homeostasis and membrane fusion.PAH1-encoded phosphatidate phosphatase plays a role in the growth phase- and inositol-mediated regulation of lipid synthesis in Saccharomyces cerevisiaeSeipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology.The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets.The cellular functions of the yeast lipin homolog PAH1p are dependent on its phosphatidate phosphatase activity.p53 as a Regulator of Lipid Metabolism in CancerTemporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1Local regulation of fat metabolism in peripheral nerves.Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factorsDGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytesSumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2A mutation in the peroxisome proliferator-activated receptor gamma-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in miceCystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney diseaseBiogenesis and functions of lipid droplets in plants: Thematic Review Series: Lipid Droplet Synthesis and Metabolism: from Yeast to ManRhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.
P2860
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P248
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P2860
Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin
description
2001 nî lūn-bûn
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2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2001 թվականի հունվարին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
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2001年论文
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name
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@ast
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@en
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@en-gb
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@nl
type
label
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@ast
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@en
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@en-gb
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@nl
prefLabel
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@ast
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@en
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@en-gb
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@nl
P2093
P3181
P356
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P1476
Lipodystrophy in the fld mouse ...... oding a nuclear protein, lipin
@en
P2093
P2888
P304
P3181
P356
10.1038/83685
P407
P50
P577
2001-01-01T00:00:00Z
P6179
1025909592