Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
about
Cherubism: best clinical practiceDifferential regulation of TCR-mediated gene transcription by Vav family membersTwo Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with VavDifferential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domainThe adaptor 3BP2 is required for KIT receptor expression and human mast cell survivalLoss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in miceBone marrow transplantation improves autoinflammation and inflammatory bone loss in SH3BP2 knock-in cherubism miceEtanercept administration to neonatal SH3BP2 knock-in cherubism mice prevents TNF-α-induced inflammation and bone loss.SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.The adaptor 3BP2 is required for early and late events in FcεRI signaling in human mast cells.3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells.Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase.The chaperone protein 14-3-3 interacts with 3BP2/SH3BP2 and regulates its adapter function.Role of protein kinase C in TBT-induced inhibition of lytic function and MAPK activation in human natural killer cells.SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis modelRNA therapeutics targeting osteoclast-mediated excessive bone resorption.The role of SH3BP2 in the pathophysiology of cherubism.Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse.3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation.The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response.Point mutations of 3BP2 identified in human-inherited disease cherubism result in the loss of function.Syk-dependent tyrosine phosphorylation of 3BP2 is required for optimal FcRγ-mediated phagocytosis and chemokine expression in U937 cells.Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism.Natural killer cells and tumor metastasis.Clinicopathologic and Molecular Characteristics of Familial Cherubism with Associated Odontogenic Tumorous Proliferations.Silencing of adaptor protein SH3BP2 reduces KIT/PDGFRA receptors expression and impairs gastrointestinal stromal tumors growth.SHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling
P2860
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P2860
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
description
2001 nî lūn-bûn
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2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@ast
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@en
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@en-gb
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@nl
type
label
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@ast
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@en
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@en-gb
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@nl
prefLabel
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@ast
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@en
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@en-gb
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@nl
P2093
P1476
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
@en
P2093
D D Billadeau
P J Leibson
R A Schoon
P304
P356
10.4049/JIMMUNOL.166.12.7219
P407
P50
P577
2001-06-01T00:00:00Z