A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5
about
Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome traffickingScreening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activityRin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradationCharacterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31Structural basis for Rab GTPase activation by VPS9 domain exchange factorsDi-Ras, a distinct subgroup of ras family GTPases with unique biochemical propertiesCrystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast.Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic.Multiple Roles of VARP in Endosomal Trafficking: Rabs, Retromer Components and R-SNARE VAMP7 Meet on VARPMice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome traffickingAlsin is a Rab5 and Rac1 guanine nucleotide exchange factorRabGEF1 is a negative regulator of mast cell activation and skin inflammationRin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cellsRisk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans.RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin.Macroarray analysis of coelomocyte gene expression in response to LPS in the sea urchin. Identification of unexpected immune diversity in an invertebrate.The ubiquitous dermokine delta activates Rab5 function in the early endocytic pathway.Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain.GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor.Rab5 isoforms orchestrate a "division of labor" in the endocytic network; Rab5C modulates Rac-mediated cell motility.Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton.A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signalingMolecular dissection of Rab11 binding from coiled-coil formation in the Rab11-FIP2 C-terminal domain.RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, and scoliosis: MACS syndromeRab5 isoforms differentially regulate the trafficking and degradation of epidermal growth factor receptorsVinculin and Rab5 complex is required [correction of requited]for uptake of Staphylococcus aureus and interleukin-6 expressionClinical and Genetic Advances in Paget's Disease of Bone: a Review.Metabolic cutis laxa syndromes.Human diseases associated with form and function of the Golgi complex.The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery.A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor.Rabaptin-5-independent membrane targeting and Rab5 activation by Rabex-5 in the cell
P2860
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P2860
A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
A novel binding protein compos ...... ties for the small GTPase Rab5
@ast
A novel binding protein compos ...... ties for the small GTPase Rab5
@en
A novel binding protein compos ...... ties for the small GTPase Rab5
@en-gb
A novel binding protein compos ...... ties for the small GTPase Rab5
@nl
type
label
A novel binding protein compos ...... ties for the small GTPase Rab5
@ast
A novel binding protein compos ...... ties for the small GTPase Rab5
@en
A novel binding protein compos ...... ties for the small GTPase Rab5
@en-gb
A novel binding protein compos ...... ties for the small GTPase Rab5
@nl
prefLabel
A novel binding protein compos ...... ties for the small GTPase Rab5
@ast
A novel binding protein compos ...... ties for the small GTPase Rab5
@en
A novel binding protein compos ...... ties for the small GTPase Rab5
@en-gb
A novel binding protein compos ...... ties for the small GTPase Rab5
@nl
P2093
P2860
P921
P356
P1476
A novel binding protein compos ...... ties for the small GTPase Rab5
@en
P2093
Hiroshi Kurosu
Kenji Kontani
Toshiaki Katada
P2860
P304
P356
10.1074/JBC.M106276200
P407
P577
2002-02-01T00:00:00Z