The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils
about
Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesoderminDifferential expression of CD300a/c on human TH1 and TH17 cellsMast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic processCD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infectionHuman CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cellsThe CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signalingGalactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissueImmunoregulatory roles of eosinophils: a new look at a familiar cellInterleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needsTherapeutic interventions in severe asthmaCD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell linesFunctional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3.Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.Eosinophil survival and apoptosis in health and disease.CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 productionHypoxia modulates human eosinophil functionThe CD300 molecules: an emerging family of regulators of the immune system.A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophilsFunctional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a.IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human EosinophilsTyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and Systemic Mastocytosis.Human versus mouse eosinophils: "that which we call an eosinophil, by any other name would stain as red".Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration.CD48 is critically involved in allergic eosinophilic airway inflammation.Peripheral CD300a+CD8+ T lymphocytes with a distinct cytotoxic molecular signature increase in pregnant women with chronic chorioamnionitis.Suppression of CD300A inhibits the growth of diffuse large B-cell lymphoma.Novel targeted therapies for eosinophilic disordersNegative signaling by inhibitory receptors: the NK cell paradigm.Human eosinophils modulate peripheral blood mononuclear cell response to Schistosoma mansoni adult worm antigen in vitroPaired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development.Immune inhibitory receptors: essential regulators of phagocyte function.Novel identified receptors on mast cells.Targeting eosinophils in allergy, inflammation and beyond.Pseudorabies Virus US3 Protein Kinase Protects Infected Cells from NK Cell-Mediated Lysis via Increased Binding of the Inhibitory NK Cell Receptor CD300a.Essential Mechanisms of Differential Activation of Eosinophils by IL-3 Compared to GM-CSF and IL-5.Cytokine induced expression of programmed death ligands in human neutrophils.sCD48 is anti-inflammatory in Staphylococcus aureus Enterotoxin B-induced eosinophilic inflammation.Functions of tissue-resident eosinophils.Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.Glycobiology of Eosinophilic Inflammation: Contributions of Siglecs, Glycans, and Other Glycan-Binding Proteins.
P2860
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P2860
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@ast
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@en
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@en-gb
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@nl
type
label
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@ast
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@en
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@en-gb
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@nl
prefLabel
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@ast
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@en
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@en-gb
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@nl
P2093
P921
P3181
P1433
P1476
The inhibitory receptor IRp60 ...... n peripheral blood eosinophils
@en
P2093
Alessandro Moretta
Ariel Munitz
Francesca Levi-Schaffer
Ido Bachelet
Lorenzo Moretta
Ron Eliashar
P304
P3181
P356
10.1182/BLOOD-2005-07-2926
P407
P577
2006-03-01T00:00:00Z