A role for alpha-synuclein in the regulation of dopamine biosynthesis
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Tyrosine hydroxylase and regulation of dopamine synthesisThe H50Q mutation enhances α-synuclein aggregation, secretion, and toxicityParkin counteracts symptoms in a Drosophila model of Parkinson's disease.Untangling the Manganese-α-Synuclein WebEmerging preclinical pharmacological targets for Parkinson's diseaseDynamic structural flexibility of α-synucleinHDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?The Synaptic Function of α-SynucleinA biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles.The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's diseaseVPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's DiseaseExpression and Transport of α-Synuclein at the Blood-Cerebrospinal Fluid Barrier and Effects of Manganese ExposureLow concentrations of methamphetamine can protect dopaminergic cells against a larger oxidative stress injury: mechanistic studyPreclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxyα-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activityIncreased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synucleinA synopsis on the role of tyrosine hydroxylase in Parkinson's diseaseDisease-toxicant interactions in Parkinson's disease neuropathologySpontaneously Hypertensive Rats (SHR) Are Resistant to a Reserpine-Induced Progressive Model of Parkinson's Disease: Differences in Motor Behavior, Tyrosine Hydroxylase and α-Synuclein ExpressionFrom QTL to candidate gene: a genetic approach to alcoholism researchAcid sensitivity and ultrastructure of the retrotrapezoid nucleus in Phox2b-EGFP transgenic mice.Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal systemDynamic transport and localization of alpha-synuclein in primary hippocampal neurons.Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.Tyrosine hydroxylase gene: another piece of the genetic puzzle of Parkinson's diseaseModulation of alpha-synuclein aggregation by dopamine analogs.Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cellsParkinson's disease-related protein, alpha-synuclein, in malignant melanomaEffect of high-fat feeding on expression of genes controlling availability of dopamine in mouse hypothalamusThe transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition.Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease.Alpha-synuclein is a cellular ferrireductase.Variants in SNCA Gene Are Associated with Parkinson's Disease Risk and Cognitive Symptoms in a Brazilian Sample.Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behaviorProgressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells.Brain disposition of α-Synuclein: roles of brain barrier systems and implications for Parkinson's disease.
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P2860
A role for alpha-synuclein in the regulation of dopamine biosynthesis
description
2002 nî lūn-bûn
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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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name
A role for alpha-synuclein in the regulation of dopamine biosynthesis
@ast
A role for alpha-synuclein in the regulation of dopamine biosynthesis
@en
A role for alpha-synuclein in the regulation of dopamine biosynthesis
@nl
type
label
A role for alpha-synuclein in the regulation of dopamine biosynthesis
@ast
A role for alpha-synuclein in the regulation of dopamine biosynthesis
@en
A role for alpha-synuclein in the regulation of dopamine biosynthesis
@nl
prefLabel
A role for alpha-synuclein in the regulation of dopamine biosynthesis
@ast
A role for alpha-synuclein in the regulation of dopamine biosynthesis
@en
A role for alpha-synuclein in the regulation of dopamine biosynthesis
@nl
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A role for alpha-synuclein in the regulation of dopamine biosynthesis
@en
P2093
Fengli Guo
Jack C Waymire
Michael J Zigmond
Ruth G Perez
P304
P3181
P356
10.1523/JNEUROSCI.22-08-03090.2002
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P577
2002-04-15T00:00:00Z