WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis
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The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complexSimilar effects of all WNK3 variants on SLC12 cotransportersWNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathwayWNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransportersThe WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transportersSLC26A9 is a Cl(-) channel regulated by the WNK kinasesMolecular physiology of the thiazide-sensitive sodium-chloride cotransporterThe thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKsWNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporterAngiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathwayRenal and brain isoforms of WNK3 have opposite effects on NCCT expressionWNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathwayMolecular regulation of NKCC2 in the thick ascending limbThe Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletionThick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSRAffinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide bindingBehavioral analysis of Ste20 kinase SPAK knockout mice.Sites of regulated phosphorylation that control K-Cl cotransporter activitySignaling mechanisms that link salt retention to hypertension: endogenous ouabain, the Na(+) pump, the Na(+)/Ca(2+) exchanger and TRPC proteins.WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule.LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity.WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathwayWNK kinases and renal sodium transport in health and disease: an integrated view.The WNKs: atypical protein kinases with pleiotropic actions.WNK4-mediated regulation of renal ion transport proteins.WNK1 kinase isoform switch regulates renal potassium excretion.Insulin resistance, obesity, hypertension, and renal sodium transport.Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line.Kidney kinase network regulates renal ion cotransportA unifying mechanism for WNK kinase regulation of sodium-chloride cotransporterDegradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic HypertensionA minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivoRegulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation.Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sitesTransport efficiency and workload distribution in a mathematical model of the thick ascending limb.Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.Multigene kinase network, kidney transport, and salt in essential hypertension.
P2860
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P248
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P2860
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@ast
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@en
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@en-gb
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@nl
type
label
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@ast
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@en
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@en-gb
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@nl
prefLabel
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@ast
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@en
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@en-gb
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@nl
P2093
P2860
P921
P356
P1476
WNK3 kinase is a positive regu ...... mal blood pressure homeostasis
@en
P2093
Frederick H Wilson
Jesse Rinehart
Kristopher T Kahle
Norma Vazquez
Paola de Los Heros
Patricia Meade
Richard P Lifton
Steven C Hebert
P2860
P304
16777-16782
P356
10.1073/PNAS.0508303102
P407
P577
2005-11-07T00:00:00Z