The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells
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CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA bindingThe PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressorsMisregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasionThe proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturationUncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epitheliumA strategy for full interrogation of prognostic gene expression patterns: exploring the biology of diffuse large B cell lymphomaImmunohistochemical staining for TLE1 distinguishes synovial sarcoma from histologic mimics.Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors.Interaction between Hhex and SOX13 modulates Wnt/TCF activityPRH/Hhex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling.The homeobox gene Hhex regulates the earliest stages of definitive hematopoiesis.AES/GRG5: more than just a dominant-negative TLE/GRG family memberHHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin.Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming abilityA mechanism of nucleocytoplasmic trafficking for the homeodomain protein PRH.Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2aPRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate.The homeodomain protein Cux1 interacts with Grg4 to repress p27 kip1 expression during kidney development.LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.The diabetes gene Hhex maintains δ-cell differentiation and islet function.NKL homeobox genes in leukemia.Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors.The Groucho/Transducin-like enhancer of split protein family in animal development.Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth.Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex.CK2 abrogates the inhibitory effects of PRH/HHEX on prostate cancer cell migration and invasion and acts through PRH to control cell proliferation.PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin.WD40 domain divergence is important for functional differences between the fission yeast Tup11 and Tup12 co-repressor proteins.DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers.Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to de-repress VEGF-signalling genes and promote cell survival.Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1.The TOPLESS interactome: a framework for gene repression in Arabidopsis.TLE forms non-functional complexes with AESHhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice
P2860
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P2860
The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells
description
2004 nî lūn-bûn
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2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
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The proline-rich homeodomain p ...... ription in hematopoietic cells
@ast
The proline-rich homeodomain p ...... ription in hematopoietic cells
@en
The proline-rich homeodomain p ...... ription in hematopoietic cells
@en-gb
The proline-rich homeodomain p ...... ription in hematopoietic cells
@nl
type
label
The proline-rich homeodomain p ...... ription in hematopoietic cells
@ast
The proline-rich homeodomain p ...... ription in hematopoietic cells
@en
The proline-rich homeodomain p ...... ription in hematopoietic cells
@en-gb
The proline-rich homeodomain p ...... ription in hematopoietic cells
@nl
prefLabel
The proline-rich homeodomain p ...... ription in hematopoietic cells
@ast
The proline-rich homeodomain p ...... ription in hematopoietic cells
@en
The proline-rich homeodomain p ...... ription in hematopoietic cells
@en-gb
The proline-rich homeodomain p ...... ription in hematopoietic cells
@nl
P2093
P2860
P921
P356
P1476
The proline-rich homeodomain p ...... ription in hematopoietic cells
@en
P2093
Kirstin L Bess
Padma-Sheela Jayaraman
Tracey E Swingler
P2860
P304
P356
10.1074/JBC.M404488200
P407
P577
2004-08-13T00:00:00Z