DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
about
Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock systemDNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei of Clock mutant miceDEC2 suppresses tumor proliferation and metastasis by regulating ERK/NF-κB pathway in gastric cancerBasic helix-loop-helix transcription factor DEC1 negatively regulates cyclin D1.Effect of DLK1 and RTL1 but not MEG3 or MEG8 on muscle gene expression in Callipyge lambs.A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation.Tumor suppression by p53: making cells senescent.DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytesThe expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter.DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence.SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP.MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle.Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanismDeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiationDifferentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1.The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor.Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells.The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice.The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancersDifferentiated embryonic chondrocyte-expressed gene 1 is associated with hypoxia-inducible factor 1α and Ki67 in human gastric cancer.Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-γ production in iNKT cells.CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell responseThe role of circadian rhythm in breast cancerThe transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs.DEC1 negatively regulates AMPK activity via LKB1.DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ΔNp73 expression.Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2.The increased expression of DEC1 gene is related to HIF-1α protein in gastric cancer cell lines.BHLHB3: a candidate tumor suppressor in lung cancer.Research progress on circadian clock genes in common abdominal malignant tumors.Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter.DEC2 Blocks the Effect of the ARNTL2/NPAS2 Dimer on the Expression of PER3 and DBP.Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP).DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression.Downregulation of DEC1 contributes to the neurotoxicity induced by MPP+ by suppressing PI3K/Akt/GSK3β pathway.Genetic interaction of Per1 and Dec1/2 in the regulation of circadian locomotor activity.Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions.
P2860
Q24293310-34A60326-BEFF-4AF0-9B2C-463EFE6F3997Q24296459-63D3F8B5-0561-4D56-B02C-2D98102D00D0Q24316223-4CD867DF-DF08-4ECC-934A-8028EAB5BE72Q28510946-2F1876C3-E3E1-4961-AE7A-EE9D63EBFC43Q28828560-7714B335-4517-45E4-80EB-FF7430BDFAA0Q30484945-EFD93362-3C7E-4F8A-84AE-2215D9AD1A1BQ33509520-DC5DF8FB-4775-4872-83C0-FB9540A6C7EBQ33648820-00DEB459-3CD5-4C7C-847C-B4B1040F6CF9Q33736728-5D9D2D3E-88C0-48F6-B257-3EA753AA24D7Q33869682-B2D2FA53-0615-4530-B6E4-FFB283690E5CQ33968314-CDD63264-BC15-44D9-815C-9B744BF7239EQ33987511-D2CE0DBF-AEBB-4E57-8C4D-B5B8DA145614Q33988687-8818FCAA-C223-46E8-959A-8FC05E09976BQ34311213-CAA830C7-C7B7-4C1C-8968-8D6B41EA60FEQ34578181-EC772F62-08B5-4A43-AD21-393FC53E0A07Q34598057-F46FBCF4-3922-48A8-845C-64B29C3C6A49Q34752036-F6959974-8F32-40A3-9BB7-6C335FFA7C6CQ36094396-EC2437A3-DEF2-44D9-AD6F-4B1EECA597F9Q36241281-0F054E3D-1B0D-4B6D-ACBD-8144622B4C36Q36289517-8F4691DD-DDE2-4956-BAAF-070CB8FF9FEBQ36615616-1D2B07B6-6684-45E8-BD74-14335FE0558BQ36695552-55E64E7D-44DF-4CD3-AEDE-3E966167964FQ36710543-68313715-3308-475A-B4EB-0078CA10ABFAQ37021675-77629100-B564-4194-9FB1-05CFBF30B5C7Q37055509-97986E13-B8C3-463D-B562-EFE3D1B428C4Q37118219-F8D4591F-BDAB-4C1C-9082-C06E4C3DD198Q38348634-7A5B3731-204B-4387-867D-E6AF13855FC3Q38825220-574EB048-1EB2-4FE1-AD8E-9B16676BAAE7Q39036140-D2C6CC71-D51B-4A56-B73A-AF5300DDAB71Q39317622-4802627A-3466-472B-A108-4B6B9773F224Q39502736-621398F2-1A06-4ACA-9805-10FC998BC804Q40020107-A2FFB7D0-5F33-40C8-A5E6-499477FB5892Q43276399-CFD325ED-8247-4DF8-B706-35FA34771FCBQ44578330-69AE8225-0BC8-4454-817A-38C43540768DQ46942289-D55D55D0-2D69-439D-98A6-993B4DC9CE82Q47967476-91CBFBC0-3D14-464F-88EA-E47A176F94F8Q48181917-69073BAA-B82A-49F1-98C3-69180D37E426Q48362528-A15B6C77-43E6-496A-AFD4-1A2BE49AAA4AQ48730406-55AD9E51-94FF-4AA2-BE74-B910DB97E400Q50350758-526F6A2F-4F6D-4BEC-B84A-DB7E9D312B9C
P2860
DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
DEC1 negatively regulates the ...... E-box in the proximal promoter
@ast
DEC1 negatively regulates the ...... E-box in the proximal promoter
@en
DEC1 negatively regulates the ...... E-box in the proximal promoter
@en-gb
DEC1 negatively regulates the ...... E-box in the proximal promoter
@nl
type
label
DEC1 negatively regulates the ...... E-box in the proximal promoter
@ast
DEC1 negatively regulates the ...... E-box in the proximal promoter
@en
DEC1 negatively regulates the ...... E-box in the proximal promoter
@en-gb
DEC1 negatively regulates the ...... E-box in the proximal promoter
@nl
prefLabel
DEC1 negatively regulates the ...... E-box in the proximal promoter
@ast
DEC1 negatively regulates the ...... E-box in the proximal promoter
@en
DEC1 negatively regulates the ...... E-box in the proximal promoter
@en-gb
DEC1 negatively regulates the ...... E-box in the proximal promoter
@nl
P2093
P2860
P356
P1476
DEC1 negatively regulates the ...... E-box in the proximal promoter
@en
P2093
Bingfang Yan
Karuna Sachdeva
Mingxing Xie
Sarah Gragen
Xiulong Song
Yinsheng Wan
P2860
P304
P356
10.1074/JBC.M300596200
P407
P577
2003-05-09T00:00:00Z