Defining human ERAD networks through an integrative mapping strategy
about
A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondriaERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptorA high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradationPolyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligasesSelenoprotein K form an intermolecular diselenide bond with unusually high redox potentialSignal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1uSGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradationSpatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnoverUSP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradationRNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complexRecent technical developments in the study of ER-associated degradationAlternative Antigen Processing for MHC Class I: Multiple Roads Lead to RomePopular computational methods to assess multiprotein complexes derived from label-free affinity purification and mass spectrometry (AP-MS) experimentsFive Questions (with their Answers) on ER-Associated DegradationCleaning up in the endoplasmic reticulum: ubiquitin in chargeEMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virusThe critical role of membralin in postnatal motor neuron survival and diseaseBOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated DegradationDimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chainsDerlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in miceSystematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.A CRISPR toolbox to study virus-host interactionsRegulation of p53wt glioma cell proliferation by androgen receptor-mediated inhibition of small VCP/p97-interacting protein expression.Live cell imaging of protein dislocation from the endoplasmic reticulum.Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylationCleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins.Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation.The final moments of misfolded proteins en route to the proteasome.Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease.The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function.Beyond hairballs: The use of quantitative mass spectrometry data to understand protein-protein interactionsBiosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex.BiP negatively affects ricin transport.Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging.PredictProtein--an open resource for online prediction of protein structural and functional features.dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors.Identification of candidate substrates for the Golgi Tul1 E3 ligase using quantitative diGly proteomics in yeast.A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death.
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Defining human ERAD networks through an integrative mapping strategy
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Defining human ERAD networks through an integrative mapping strategy
@ast
Defining human ERAD networks through an integrative mapping strategy
@en
Defining human ERAD networks through an integrative mapping strategy
@en-gb
Defining human ERAD networks through an integrative mapping strategy
@nl
type
label
Defining human ERAD networks through an integrative mapping strategy
@ast
Defining human ERAD networks through an integrative mapping strategy
@en
Defining human ERAD networks through an integrative mapping strategy
@en-gb
Defining human ERAD networks through an integrative mapping strategy
@nl
prefLabel
Defining human ERAD networks through an integrative mapping strategy
@ast
Defining human ERAD networks through an integrative mapping strategy
@en
Defining human ERAD networks through an integrative mapping strategy
@en-gb
Defining human ERAD networks through an integrative mapping strategy
@nl
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Defining human ERAD networks through an integrative mapping strategy
@en
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Caleb M Richter
Eric J Bennett
Ethan J Greenblatt
J Wade Harper
John C Christianson
Mathew E Sowa
Ron R Kopito
Ryan E Tyler
Thomas A Shaler
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10.1038/NCB2383
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2012-01-01T00:00:00Z
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1044472122