Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.
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GWAS of 126,559 individuals identifies genetic variants associated with educational attainmentTurning the RING domain protein MdmX into an active ubiquitin-protein ligaseMDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosisEffects of MdmX on Mdm2-mediated downregulation of pRBRegulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activationPhosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 bindingAn essential function of the extreme C-terminus of MDM2 can be provided by MDMXMdmX is a substrate for the deubiquitinating enzyme USP2aMDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayDNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyDeubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delaminationCrystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational ChangesStapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapyRole of MDM2 and MDMX in DNA repairBeta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2Hdmx modulates the outcome of p53 activation in human tumor cellsG1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target PtprvTP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephantsMDM2 and MDMX: Alone and together in regulation of p53Modes of p53 regulationRegulating the p53 pathway: in vitro hypotheses, in vivo veritasp53 ubiquitination: Mdm2 and beyondp53 pathway is involved in cell competition during mouse embryogenesisMDM4 (MDMX) and its Transcript Variants.Genome wide analysis of human genes transcriptionally and post-transcriptionally regulated by the HTLV-I protein p30.Identification and characterization of the first small molecule inhibitor of MDMXPredicted functions of MdmX in fine-tuning the response of p53 to DNA damage.Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activityThe regulation of the p53-mediated stress response by MDM2 and MDM4.Tumorigenesis promotes Mdm4-S overexpression.Mdm proteins: critical regulators of embry ogenesis and homeostasis.The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation.Mouse models of p53 functions.The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation.Regulation of p53-MDMX interaction by casein kinase 1 alpha.p53 at a glance.ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
P2860
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P2860
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.
description
2002 nî lūn-bûn
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2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Mdm4 (Mdmx) regulates p53-indu ...... ly embryonic mouse development
@nl
Mdm4 (Mdmx) regulates p53-indu ...... y embryonic mouse development.
@ast
Mdm4 (Mdmx) regulates p53-indu ...... y embryonic mouse development.
@en
Mdm4 (Mdmx) regulates p53-indu ...... y embryonic mouse development.
@en-gb
type
label
Mdm4 (Mdmx) regulates p53-indu ...... ly embryonic mouse development
@nl
Mdm4 (Mdmx) regulates p53-indu ...... y embryonic mouse development.
@ast
Mdm4 (Mdmx) regulates p53-indu ...... y embryonic mouse development.
@en
Mdm4 (Mdmx) regulates p53-indu ...... y embryonic mouse development.
@en-gb
prefLabel
Mdm4 (Mdmx) regulates p53-indu ...... ly embryonic mouse development
@nl
Mdm4 (Mdmx) regulates p53-indu ...... y embryonic mouse development.
@ast
Mdm4 (Mdmx) regulates p53-indu ...... y embryonic mouse development.
@en
Mdm4 (Mdmx) regulates p53-indu ...... y embryonic mouse development.
@en-gb
P2093
P2860
P50
P3181
P1476
Mdm4 (Mdmx) regulates p53-indu ...... y embryonic mouse development.
@en
P2093
Aart Jochemsen
Alberto Gobbi
Domenico Migliorini
Manuela Capillo
Pier Giuseppe Pelicci
P2860
P304
P3181
P356
10.1128/MCB.22.15.5527-5538.2002
P407
P577
2002-08-01T00:00:00Z