Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter
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Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical ImplicationsIloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungsAn evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing.Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease.PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationThe human near-term myometrial beta 3-adrenoceptor but not the beta 2-adrenoceptor is resistant to desensitisation after sustained agonist stimulation.Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury.G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.Phosphodiesterase-4 inhibitors as a novel approach for the treatment of respiratory disease: cilomilast.Alteration of genomic responses to doxorubicin and prevention of MDR in breast cancer cells by a polymer excipient: pluronic P85.Cyclic nucleotide signaling in polycystic kidney disease.DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1.Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease.Mechanism regulating proasthmatic effects of prolonged homologous beta2-adrenergic receptor desensitization in airway smooth muscle.A whole genome association study of neuroticism using DNA pooling.Novel cAMP signalling paradigms: therapeutic implications for airway diseaseMultiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.Dual PDE3/4 and PDE4 inhibitors: novel treatments for COPD and other inflammatory airway diseases.Phosphodiesterase type 4D gene polymorphism: association with the response to short-acting bronchodilators in paediatric asthma patients.RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase geneNovel polymorphisms influencing transcription of the human CHRM2 gene in airway smooth muscle.Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma modelImportance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes.Real time analysis of β(2)-adrenoceptor-mediated signaling kinetics in human primary airway smooth muscle cells reveals both ligand and dose dependent differences.PGE 2 desensitizes β -agonist effect on human lung fibroblast-mediated collagen gel contraction through upregulating PDE4.Changes in NMDA receptor-induced cyclic nucleotide synthesis regulate the age-dependent increase in PDE4A expression in primary cortical cultures.Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/cyclic AMP-response element binding protein pathway in primary striatal neurons.Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction.Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers.The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells.PDK1/Akt/PDE4D axis identified as a target for asthma remedy synergistic with β2 AR agonists by a natural agent arctigenin.
P2860
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P2860
Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@ast
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@en
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@en-gb
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@nl
type
label
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@ast
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@en
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@en-gb
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@nl
prefLabel
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@ast
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@en
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@en-gb
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@nl
P2093
P2860
P3181
P356
P1476
Cyclic AMP-dependent transcrip ...... ion of a novel PDE4D5 promoter
@en
P2093
Gino Van Heeke
Ivan R Le Jeune
Malcolm Shepherd
P2860
P304
P3181
P356
10.1074/JBC.M204832200
P407
P577
2002-09-27T00:00:00Z