Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling
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The neural crest in cardiac congenital anomaliesMolecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 MutationsStructural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan SyndromeShp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in miceStructural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesityDisorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanismsRapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.Noonan syndrome and clinically related disorders.The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration.Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.Elevated Ca2+ transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan syndrome with multiple lentigines.PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?Cardiomyopathies in Noonan syndrome and the other RASopathies.Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice.Distinct and overlapping functions of ptpn11 genes in Zebrafish development.New approaches to prevent LEOPARD syndrome-associated cardiac hypertrophy by specifically targeting Shp2-dependent signaling.LEOPARD-type SHP2 mutant Gln510Glu attenuates cardiomyocyte differentiation and promotes cardiac hypertrophy via dysregulation of Akt/GSK-3β/β-catenin signaling.Identification of new substrates of the protein-tyrosine phosphatase PTP1B by Bayesian integration of proteome evidence.ROCKs cause SHP-wrecks and broken hearts.A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.Heterozygous deletion of AKT1 rescues cardiac contractility, but not hypertrophy, in a mouse model of Noonan Syndrome with Multiple Lentigines.MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development.Congenital heart disease and genetic syndromes: new insights into molecular mechanisms.Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.
P2860
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P2860
Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling
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2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
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Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
@en
Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
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Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
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type
label
Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
@ast
Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
@en
Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
@en-gb
Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
@nl
prefLabel
Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
@ast
Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
@en
Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
@en-gb
Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
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P2093
P2860
P50
P356
P1476
Functional effects of PTPN11 ( ...... ynthase kinase 3beta signaling
@en
P2093
Audrey Nédélec
Béatrice Parfait
Francoise Conte-Auriol
Jean-Philippe Combier
Jean-Pierre Salles
Maithé Tauber
Patrick Raynal
Sophie Bel-Vialar
P2860
P304
P356
10.1128/MCB.00646-09
P407
P577
2010-05-01T00:00:00Z