The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease
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Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transductionCharcot-Marie-Tooth disease and intracellular trafficDefective membrane remodeling in neuromuscular diseases: insights from animal modelsPhosphoinositides: tiny lipids with giant impact on cell regulationCaenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cellsCrystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate SpecificityMulti-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2The pseudophosphatase MK-STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP-1The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formationMissense mutations in the SH3TC2 protein causing Charcot-Marie-Tooth disease type 4C affect its localization in the plasma membrane and endocytic pathway.Identification of a novel SBF2 frameshift mutation in charcot-marie-tooth disease type 4B2 using whole-exome sequencing.Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration.Class II formin targeting to the cell cortex by binding PI(3,5)P(2) is essential for polarized growth.Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathwaysIdentification of a novel SBF2 missense mutation associated with a rare case of thrombocytopenia using whole-exome sequencing.The role of PI3P phosphatases in the regulation of autophagyEndosomal targeting of the phosphoinositide 3-phosphatase MTMR2 is regulated by an N-terminal phosphorylation site.The myotubularin family of lipid phosphatases in disease and in spermatogenesisPhosphoinositides and vesicular membrane trafficSbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling.Mutations in phosphoinositide metabolizing enzymes and human disease.Autosomal-recessive forms of demyelinating Charcot-Marie-Tooth disease.Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease.Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice.The role of myotubularin-related phosphatases in the control of autophagy and programmed cell deathThe CMT4B disease-causing phosphatases Mtmr2 and Mtmr13 localize to the Schwann cell cytoplasm and endomembrane compartments, where they depend upon each other to achieve wild-type levels of protein expression.Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking.Molecular mechanisms of inherited demyelinating neuropathies.Endosomal phosphoinositides and human diseases.Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease.DENN domain proteins: regulators of Rab GTPases.Demyelinating prenatal and infantile developmental neuropathies.The extended human PTPome: a growing tyrosine phosphatase family.Dysregulation of ErbB Receptor Trafficking and Signaling in Demyelinating Charcot-Marie-Tooth Disease.Antagonistic roles for STYX pseudophosphatases in neurite outgrowth.Autophagy as an Emerging Common Pathomechanism in Inherited Peripheral Neuropathies.Occurrence of Optic Neuritis and Cervical Cord Schwannoma with Charcot-Marie-Tooth Type 4B1 DiseaseStarvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis.
P2860
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P2860
The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年學術文章
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name
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@ast
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@en
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@en-gb
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@nl
type
label
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@ast
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@en
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@en-gb
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@nl
prefLabel
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@ast
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@en
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@en-gb
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@nl
P2860
P3181
P356
P1476
The phosphoinositide-3-phospha ...... 4B Charcot-Marie-Tooth disease
@en
P2093
Fred L Robinson
Jack E Dixon
P2860
P304
P3181
P356
10.1074/JBC.M505159200
P407
P577
2005-09-09T00:00:00Z