about
A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNASDifferential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreasAn imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locusOscillating evolution of a mammalian locus with overlapping reading frames: an XLalphas/ALEX relay.The GNAS complex locus and human diseases associated with loss-of-function mutations or epimutations within this imprinted geneTwo overlapping reading frames in a single exon encode interacting proteins--a novel way of gene usageGNAS locus and pseudohypoparathyroidismCharacterization of heterotrimeric G protein complexes in rice plasma membraneXLalphas, the extra-long form of the alpha-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion AlexA novel form of the G protein β Subunit Gβ5 is specifically expressed in the vertebrate retinaTransgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivoA proline-rich region and nearby cysteine residues target XLalphas to the Golgi complex regionPaternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolismGsαMutations and Imprinting Defects in Human DiseaseRat cerebral cortex corticotropin-releasing hormone receptors: evidence for receptor coupling to multiple G-proteins.The pituitary adenylate cyclase-activating polypeptide is a physiological inhibitor of platelet activation.Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteinsPseudohypoparathyroidism: from bedside to bench and back.Imprinted Nesp55 influences behavioral reactivity to novel environmentsVariable imprinting of the heterotrimeric G protein G(s) alpha-subunit within different segments of the nephron.Identification of a methylation imprint mark within the mouse Gnas locus.Deletion of the noncoding GNAS antisense transcript causes pseudohypoparathyroidism type Ib and biparental defects of GNAS methylation in cisThe role of GNAS and other imprinted genes in the development of obesity.Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice.Alternative transcripts and evidence of imprinting of GNAL on 18p11.2.Potent constitutive cyclic AMP-generating activity of XLαs implicates this imprinted GNAS product in the pathogenesis of McCune-Albright syndrome and fibrous dysplasia of bone.The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult miceEffects of deficiency of the G protein Gsα on energy and glucose homeostasisRadial glia diversity: a matter of cell fate.Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus.Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signalingA winged-helix transcription factor foxg1 induces expression of mss4 gene in rat hippocampal progenitor cellsGNAS Spectrum of Disorders.New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism but not in suckling.Loss of XLαs (extra-large αs) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib.Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells.Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo.Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS.The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins
P2860
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P2860
description
1994 nî lūn-bûn
@nan
1994 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
XL alpha s is a new type of G protein
@ast
XL alpha s is a new type of G protein
@en
XL alpha s is a new type of G protein
@en-gb
XL alpha s is a new type of G protein
@nl
type
label
XL alpha s is a new type of G protein
@ast
XL alpha s is a new type of G protein
@en
XL alpha s is a new type of G protein
@en-gb
XL alpha s is a new type of G protein
@nl
prefLabel
XL alpha s is a new type of G protein
@ast
XL alpha s is a new type of G protein
@en
XL alpha s is a new type of G protein
@en-gb
XL alpha s is a new type of G protein
@nl
P2093
P356
P1433
P1476
XL alpha s is a new type of G protein
@en
P2093
R H Kehlenbach
W B Huttner
P2888
P356
10.1038/372804A0
P407
P577
1994-12-01T00:00:00Z
P6179
1021890463