Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities
about
Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentationHuman VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expressionVRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damageVaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damageVRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damageStructure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding SiteMice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.Differential inhibitor sensitivity between human kinases VRK1 and VRK2.Functional disruption of the moloney murine leukemia virus preintegration complex by vaccinia-related kinases.VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycleMitogen-activated protein kinase phosphatase 2 regulates histone H3 phosphorylation via interaction with vaccinia-related kinase 1.Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC.H3 phosphorylation: dual role in mitosis and interphase.Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiationVRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals.
P2860
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P2860
Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Proteomics identification of n ...... nia-related kinase) activities
@ast
Proteomics identification of n ...... nia-related kinase) activities
@en
Proteomics identification of n ...... nia-related kinase) activities
@en-gb
Proteomics identification of n ...... nia-related kinase) activities
@nl
type
label
Proteomics identification of n ...... nia-related kinase) activities
@ast
Proteomics identification of n ...... nia-related kinase) activities
@en
Proteomics identification of n ...... nia-related kinase) activities
@en-gb
Proteomics identification of n ...... nia-related kinase) activities
@nl
prefLabel
Proteomics identification of n ...... nia-related kinase) activities
@ast
Proteomics identification of n ...... nia-related kinase) activities
@en
Proteomics identification of n ...... nia-related kinase) activities
@en-gb
Proteomics identification of n ...... nia-related kinase) activities
@nl
P2093
P2860
P3181
P1476
Proteomics identification of n ...... nia-related kinase) activities
@en
P2093
Inmaculada López-Sánchez
Marta Sanz-García
Pedro A Lazo
P2860
P304
P3181
P356
10.1074/MCP.M700586-MCP200
P407
P577
2008-11-01T00:00:00Z