Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
about
RanGTP and CLASP1 cooperate to position the mitotic spindle.Cortical dynein is critical for proper spindle positioning in human cellsThe Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis.MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosisLocalization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell divisionRobust spindle alignment in Drosophila neuroblasts by ultrasensitive activation of pinsGalphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblastsCytoskeletal dynamics: a view from the membraneCancer stem cell division: when the rules of asymmetry are brokenEmerging role of cell polarity proteins in breast cancer progression and metastasisEpithelial homeostasisActivators of G protein signaling exhibit broad functionality and define a distinct core signaling triadOriented cell division: new roles in guiding skin wound repair and regenerationMolecular pathways regulating mitotic spindle orientation in animal cellsMultisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegansInterphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1.Par1b induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytesResistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activityA cell cycle timer for asymmetric spindle positioningStructure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteriaLGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA PathwaysStructural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisionsConcomitant binding of Afadin to LGN and F-actin directs planar spindle orientationCoactivation of G protein signaling by cell-surface receptors and an intracellular exchange factorCrystal structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from GαiRGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathwaysActivation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8AThe PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteinsAsymmetric cell divisions promote stratification and differentiation of mammalian skin.NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein functionChromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientationNuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic SpindleCell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation.Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells.Ric-8: different cellular roles for a heterotrimeric G-protein GEF.Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical PinsTuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation.
P2860
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P2860
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@ast
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@en
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@en-gb
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@nl
type
label
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@ast
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@en
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@en-gb
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@nl
prefLabel
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@ast
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@en
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@en-gb
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@nl
P3181
P1433
P1476
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
@en
P2093
Ian G Macara
P304
P3181
P356
10.1016/J.CELL.2004.10.028
P407
P50
P577
2004-11-12T00:00:00Z