Histone deacetylase 6 interacts with the microtubule-associated protein tau
about
HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylationTau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective StrategiesEpigenetic Alterations in Alzheimer's DiseaseTargeting New Candidate Genes by Small Molecules Approaching Neurodegenerative DiseasesEpigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug ResponseDirect and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein ToxicityThe Possible Roles of the Dentate Granule Cell's Leptin and Other Ciliary Receptors in Alzheimer's NeuropathologyEpigenetics of Alzheimer's disease and frontotemporal dementiaHDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neuronsHDAC6 regulates mitochondrial transport in hippocampal neuronsEpigenetic Changes in Neurodegenerative DiseasesAberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predisposes to anxiety and alcoholism.HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytesHdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's diseaseHistone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition.Proteasome inhibition drives HDAC6-dependent recruitment of tau to aggresomes.Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's diseaseRoles of tau protein in health and disease.Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development.Acetylation: a new key to unlock tau's role in neurodegenerationHDAC6 regulates LPS-tolerance in astrocytes.Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behavioursLoss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulationEpigenetic memory: the Lamarckian brainSearching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stressThe role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?Targeting HDACs: a promising therapy for Alzheimer's disease.Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356.Metabolism as a key to histone deacetylase inhibition.Lessons from tau-deficient miceConcomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease.Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies.Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulationHDAC6 mutations rescue human tau-induced microtubule defects in Drosophila.Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's diseaseAmyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific mannerAcetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance.
P2860
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P2860
Histone deacetylase 6 interacts with the microtubule-associated protein tau
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@ast
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@en
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@en-gb
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@nl
type
label
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@ast
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@en
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@en-gb
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@nl
prefLabel
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@ast
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@en
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@en-gb
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@nl
P2093
P2860
P921
P3181
P1476
Histone deacetylase 6 interacts with the microtubule-associated protein tau
@en
P2093
Gail V W Johnson
Huiping Ding
Philip J Dolan
P2860
P304
P3181
P356
10.1111/J.1471-4159.2008.05564.X
P407
P577
2008-09-01T00:00:00Z