A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor
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An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerasesRemoval of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmiasBcl-2 regulator FKBP38 is activated by Ca2+/calmodulin.Immunogenetics of Hashimoto's thyroiditisLarge FK506-Binding Proteins Shape the Pharmacology of RapamycinAnalysing the visible conformational substates of the FK506-binding protein FKBP12Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6Modulation of type-1 Ins(1,4,5)P3 receptor channels by the FK506-binding protein, FKBP12FKBP12 modulation of the binding of the skeletal ryanodine receptor onto the II-III loop of the dihydropyridine receptor.Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in miceFKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cellsCardiac defects and altered ryanodine receptor function in mice lacking FKBP12The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia.Cyclic ADP-ribose as a potential second messenger for neuronal Ca2+ signaling.Cryoelectron microscopy and image analysis of the cardiac ryanodine receptor.FK-binding protein is associated with the ryanodine receptor of skeletal muscle in vertebrate animals.The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different.FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.Signal transduction from bradykinin, angiotensin, adrenergic and muscarinic receptors to effector enzymes, including ADP-ribosyl cyclase.Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptorNocardiopsis species: a potential source of bioactive compounds.Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107Functional role of Calstabin2 in age-related cardiac alterations.Regulation of Ryanodine Receptor Ion Channels Through Posttranslational Modifications.Biphasic effect of bimoclomol on calcium handling in mammalian ventricular myocardium.A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber typeStatistical allosteric coupling to the active site indole ring flip equilibria in the FK506-binding domain.Regulation of myosin heavy chain expression during rat skeletal muscle development in vitro.Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities.Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition.Alterations in ryanodine receptors and related proteins in heart failureComparative differential proteomic profiles of nonfailing and failing hearts after in vivo thoracic aortic constriction in mice overexpressing FKBP12.6.Effects of FK506 on ca release channels (review)Role of ryanodine receptor subtypes in initiation and formation of calcium sparks in arterial smooth muscle: comparison with striated muscle.Conformational Dynamics in FKBP Domains: Relevance to Molecular Signaling and Drug DesignFK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge.Murine Electrophysiological Models of Cardiac Arrhythmogenesis.FKBP12.6 activates RyR1: investigating the amino acid residues critical for channel modulation.Chicken FK506-binding protein, FKBP65, a member of the FKBP family of peptidylprolyl cis-trans isomerases, is only partially inhibited by FK506.
P2860
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P2860
A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@ast
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@en
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@en-gb
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@nl
type
label
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@ast
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@en
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@en-gb
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@nl
prefLabel
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@ast
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@en
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@en-gb
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@nl
P2093
P2860
P921
P356
P1476
A novel FK506 binding protein ...... the cardiac ryanodine receptor
@en
P2093
A P Timerman
E A O'Neill
G J Wiederrecht
M M Martin
R T Abraham
S Fleischer
S J O'Keefe
P2860
P304
P356
10.1074/JBC.270.44.26511
P407
P577
1995-11-03T00:00:00Z