The complete primary structure of human nebulin and its correlation to muscle structure
about
Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assemblyNebulin regulates thin filament length, contractility, and Z-disk structure in vivo.ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disksMolecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.Mutations in the nebulin gene associated with autosomal recessive nemaline myopathyLasp-1, a novel type of actin-binding protein accumulating in cell membrane extensionsDifferentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling proteinTropomodulin capping of actin filaments in striated muscle development and physiologyCrystal structure of the C-terminal half of tropomodulin and structural basis of actin filament pointed-end capping.Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodelingThe vertebrate muscle Z-disc: sarcomere anchor for structure and signallingThe Nebulin family: an actin support groupHow Cells Measure Length on Subcellular ScalesA nebulin ruler does not dictate thin filament lengthsDistinct families of Z-line targeting modules in the COOH-terminal region of nebulin.The Caenorhabditis elegans gene unc-89, required fpr muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domainsMyofibril assembly visualized by imaging N-RAP, alpha-actinin, and actin in living cardiomyocytes.Nebulin binding impedes mutant desmin filament assembly.Chromosomal attachments set length and microtubule number in the Saccharomyces cerevisiae mitotic spindle.Modular motif, structural folds and affinity profiles of the PEVK segment of human fetal skeletal muscle titin.Nanomechanics of full-length nebulin: an elastic strain gauge in the skeletal muscle sarcomereNebulin plays a direct role in promoting strong actin-myosin interactions.Differential splicing of the large sarcomeric protein nebulin during skeletal muscle developmentAltered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2).Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle.Nebulin regulates actin filament lengths by a stabilization mechanism.New insights into the structural roles of nebulin in skeletal muscle.Actin-titin interaction in cardiac myofibrils: probing a physiological role.Nebulin interactions with actin and tropomyosin are altered by disease-causing mutations.Expression and purification of large nebulin fragments and their interaction with actin.Biochemical characterization of the cell-biomaterial interface by quantitative proteomics.Fishing out proteins that bind to titinAutosomal dominant myopathy with proximal weakness and early respiratory muscle involvement maps to chromosome 2q.Nebulin, a major player in muscle health and diseaseFast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency.Muscle giants: molecular scaffolds in sarcomerogenesis.Mutation update: the spectra of nebulin variants and associated myopathies.The desmin coil 1B mutation K190A impairs nebulin Z-disc assembly and destabilizes actin thin filaments.The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimizationNebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers.
P2860
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P2860
The complete primary structure of human nebulin and its correlation to muscle structure
description
1995 nî lūn-bûn
@nan
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
The complete primary structure of human nebulin and its correlation to muscle structure
@ast
The complete primary structure of human nebulin and its correlation to muscle structure
@en
The complete primary structure of human nebulin and its correlation to muscle structure
@en-gb
The complete primary structure of human nebulin and its correlation to muscle structure
@nl
type
label
The complete primary structure of human nebulin and its correlation to muscle structure
@ast
The complete primary structure of human nebulin and its correlation to muscle structure
@en
The complete primary structure of human nebulin and its correlation to muscle structure
@en-gb
The complete primary structure of human nebulin and its correlation to muscle structure
@nl
prefLabel
The complete primary structure of human nebulin and its correlation to muscle structure
@ast
The complete primary structure of human nebulin and its correlation to muscle structure
@en
The complete primary structure of human nebulin and its correlation to muscle structure
@en-gb
The complete primary structure of human nebulin and its correlation to muscle structure
@nl
P1476
The complete primary structure of human nebulin and its correlation to muscle structure
@en
P2093
P304
P356
10.1016/S0022-2836(95)80052-2
P407
P577
1995-04-28T00:00:00Z