Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease
about
EH domain proteins regulate cardiac membrane protein targetingAlpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel)Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillationAnkyrin-B regulates Kir6.2 membrane expression and function in heartIon Channels in the HeartNa+ channel function, regulation, structure, trafficking and sequestrationMechanisms of altered Ca²⁺ handling in heart failureIdentification and characterization of two ankyrin-B isoforms in mammalian heart.Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channelThe cardiac conduction systemInteractions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated discG protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome.I(f) and SR Ca(2+) release both contribute to pacemaker activity in canine sinoatrial node cellsA coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.Heart rhythm genomic fabric in hypoxiaEHD3-dependent endosome pathway regulates cardiac membrane excitability and physiology.From Fifth Business to Protagonist: the complex roles of ion channel anchors in cardiac arrhythmia.Functional anatomy of the murine sinus node: high-resolution optical mapping of ankyrin-B heterozygous miceDefining new insight into atypical arrhythmia: a computational model of ankyrin-B syndromeAnkyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity.Ankyrin-B protein in heart failure: identification of a new component of metazoan cardioprotection.Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node.CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: a computational analysis.Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivoCardiac ankyrins in health and diseaseFrom two competing oscillators to one coupled-clock pacemaker cell systemCycle length restitution in sinoatrial node cells: a theory for understanding spontaneous action potential dynamics.Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firingDysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia.Structural basis of diverse membrane target recognitions by ankyrins.Coordinating electrical activity of the heart: ankyrin polypeptides in human cardiac disease.Oxidized CaMKII causes cardiac sinus node dysfunction in mice.Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice.Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease.Defects in cytoskeletal signaling pathways, arrhythmia, and sudden cardiac death.Transcription factor ISL1 is essential for pacemaker development and function.Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy.Cell-cell junction remodeling in the heart: possible role in cardiac conduction system function and arrhythmias?
P2860
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P2860
Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@ast
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@en
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@en-gb
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@nl
type
label
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@ast
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@en
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@en-gb
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@nl
prefLabel
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@ast
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@en
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@en-gb
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Dysfunction in ankyrin-B-depen ...... auses human sinus node disease
@en
P2093
Celine Marionneau
Claude Vieyres
Long-Sheng Song
Mark E Anderson
Naina Bhasin
Olha Koval
Peter J Mohler
Shane R Cunha
Thomas J Hund
P2860
P304
P3181
P356
10.1073/PNAS.0805500105
P407
P577
2008-10-07T00:00:00Z