Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements
about
From dynamic expression patterns to boundary formation in the presomitic mesodermA human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promotersHERP, a novel heterodimer partner of HES/E(spl) in Notch signalingHairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding siteBinding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activationMediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiationRepression by Groucho/TLE/Grg proteins: genomic site recruitment generates compacted chromatin in vitro and impairs activator binding in vivoMembers of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signalingDelta-Notch signalling in segmentationHES1 is a novel interactor of the Fanconi anemia core complexComputational models of the Notch network elucidate mechanisms of context-dependent signalingHes1 and Hes5 as notch effectors in mammalian neuronal differentiation.Multiple requirements for Hes 1 during early eye formationHes1 directly controls cell proliferation through the transcriptional repression of p27Kip1RBP-L, a transcription factor related to RBP-JkappaCross-regulation between Notch and p63 in keratinocyte commitment to differentiationThe WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domainId2 is required for specification of dopaminergic neurons during adult olfactory neurogenesisSpatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation.Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock.T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.Prox1 regulates the notch1-mediated inhibition of neurogenesis.Stochastic simulation of notch signaling reveals novel factors that mediate the differentiation of neural stem cells.Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling.The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1MicroRNA-9 Modulates Hes1 ultradian oscillations by forming a double-negative feedback loop.HES-1 repression of differentiation and proliferation in PC12 cells: role for the helix 3-helix 4 domain in transcription repression.Expression of the oscillating gene her1 is directly regulated by Hairy/Enhancer of Split, T-box, and Suppressor of Hairless proteins in the zebrafish segmentation clock.Trp53 regulates Notch 4 signaling through Mdm2.The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance.HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumorsTargeting HIF1α eliminates cancer stem cells in hematological malignancies.Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells.Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo.Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms.In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters.SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers.Xanthohumol-Mediated Suppression of Notch1 Signaling Is Associated with Antitumor Activity in Human Pancreatic Cancer Cells.Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour.
P2860
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P2860
Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements
description
1994 nî lūn-bûn
@nan
1994 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Structure, chromosomal locus, ...... gh the multiple N box elements
@ast
Structure, chromosomal locus, ...... gh the multiple N box elements
@en
Structure, chromosomal locus, ...... gh the multiple N box elements
@en-gb
Structure, chromosomal locus, ...... gh the multiple N box elements
@nl
type
label
Structure, chromosomal locus, ...... gh the multiple N box elements
@ast
Structure, chromosomal locus, ...... gh the multiple N box elements
@en
Structure, chromosomal locus, ...... gh the multiple N box elements
@en-gb
Structure, chromosomal locus, ...... gh the multiple N box elements
@nl
prefLabel
Structure, chromosomal locus, ...... gh the multiple N box elements
@ast
Structure, chromosomal locus, ...... gh the multiple N box elements
@en
Structure, chromosomal locus, ...... gh the multiple N box elements
@en-gb
Structure, chromosomal locus, ...... gh the multiple N box elements
@nl
P2093
P1476
Structure, chromosomal locus, ...... gh the multiple N box elements
@en
P2093
P304
P407
P577
1994-02-01T00:00:00Z