Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain
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Molecular Pathological Classification of Neurodegenerative Diseases: Turning towards Precision MedicineGut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?Immunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein AggregationPropagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in MacaqueThe Monoamine Brainstem Reticular Formation as a Paradigm for Re-Defining Various Phenotypes of Parkinson's Disease Owing Genetic and Anatomical Specificity.Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in miceExPLAining early synucleinopathies.Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease.The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity.Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents.Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients.Targeting α-synuclein as a therapeutic strategy for Parkinson's disease.Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Neuropathology of α-synuclein propagation and braak hypothesis.Review: Parkinson's disease: from synaptic loss to connectome dysfunction.Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Development of Passive Immunotherapies for Synucleinopathies.Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD.Synaptic failure and α-synuclein.ɑ-Synuclein strains and the variable pathologies of synucleinopathies.How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Potential mechanisms and implications for the formation of tau oligomeric strains.Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology.The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases.Looking at the recent advances in understanding α-synuclein and its aggregation through the proteoform prism.Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles.AMBRA1, a novel α-synuclein-binding protein, is implicated in the pathogenesis of multiple system atrophy.Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice.DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy.MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency.Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice.Alpha-synuclein oligomers: a new hope.Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide.Parkinson's Disease Is Not Simply a Prion Disorder.Alpha-synuclein, proteotoxicity and Parkinson's disease: Search for neuroprotective therapy.A Focus on the Beneficial Effects of Alpha Synuclein and a Re-appraisal of Synucleinopathies.Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain.
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P2860
Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain
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2015 nî lūn-bûn
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2015 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2015 թվականի հունիսին հրատարակված գիտական հոդված
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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name
Direct visualization of alpha- ...... y in Parkinson's disease brain
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Direct visualization of alpha- ...... y in Parkinson's disease brain
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Direct visualization of alpha- ...... y in Parkinson's disease brain
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Direct visualization of alpha- ...... y in Parkinson's disease brain
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label
Direct visualization of alpha- ...... y in Parkinson's disease brain
@ast
Direct visualization of alpha- ...... y in Parkinson's disease brain
@en
Direct visualization of alpha- ...... y in Parkinson's disease brain
@en-gb
Direct visualization of alpha- ...... y in Parkinson's disease brain
@nl
prefLabel
Direct visualization of alpha- ...... y in Parkinson's disease brain
@ast
Direct visualization of alpha- ...... y in Parkinson's disease brain
@en
Direct visualization of alpha- ...... y in Parkinson's disease brain
@en-gb
Direct visualization of alpha- ...... y in Parkinson's disease brain
@nl
P2860
P921
P356
P1433
P1476
Direct visualization of alpha- ...... y in Parkinson's disease brain
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P2093
Javier Alegre-Abarrategui
Rosalind F Roberts
P2860
P304
P356
10.1093/BRAIN/AWV040
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P577
2015-03-01T00:00:00Z