TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein
about
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondriaTwinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stallingMitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cellsHuman DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediatesHuman Dna2 is a nuclear and mitochondrial DNA maintenance proteinTwinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNAReconstitution of a minimal mtDNA replisome in vitroGenome-wide comprehensive analysis of human helicasesThe mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesisModular architecture of the hexameric human mitochondrial DNA helicaseG-quadruplexes and helicasesRoles of DNA helicases in the maintenance of genome integrityAtaxia.Infantile onset spinocerebellar ataxia is caused by recessive mutations in mitochondrial proteins Twinkle and TwinkyAlkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy numberFunctional roles of the N- and C-terminal regions of the human mitochondrial single-stranded DNA-binding proteinIn vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replicationBiochemical Characterization of a Mycobacteriophage Derived DnaB Ortholog Reveals New Insight into the Evolutionary Origin of DnaB HelicasesNovel subcellular localization of the DNA helicase Twinkle at the kinetochore complex during mitosis in neuronal-like progenitor cells.DNA unwinding assay using streptavidin-bound oligonucleotides.Preparation of human mitochondrial single-stranded DNA-binding protein.CKS proteins protect mitochondrial genome integrity by interacting with mitochondrial single-stranded DNA-binding protein.Unraveling the structure of DNA during overstretching by using multicolor, single-molecule fluorescence imagingTenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicityDynamic effects of cofactors and DNA on the oligomeric state of human mitochondrial DNA helicase.DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein.Defects of mitochondrial DNA replication.Mitochondrial helicases and mitochondrial genome maintenanceThe N-terminal domain of the Drosophila mitochondrial replicative DNA helicase contains an iron-sulfur cluster and binds DNADisease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.Mitochondrial DNA polymerase-gamma and human disease.The Arabidopsis At1g30680 gene encodes a homologue to the phage T7 gp4 protein that has both DNA primase and DNA helicase activities.The overexpression of Twinkle helicase ameliorates the progression of cardiac fibrosis and heart failure in pressure overload model in mice.SLC25A4 and C10ORF2 Mutations in Autosomal Dominant Progressive External Ophthalmoplegia.The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimersReduced stimulation of recombinant DNA polymerase γ and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells.Evolution of the metazoan mitochondrial replicase.Maintaining ancient organelles: mitochondrial biogenesis and maturation.The awakening of an advanced malignant cancer: an insult to the mitochondrial genome
P2860
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P2860
TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@ast
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@en
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@en-gb
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@nl
type
label
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@ast
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@en
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@en-gb
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@nl
prefLabel
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@ast
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@en
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@en-gb
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@nl
P2860
P921
P3181
P356
P1476
TWINKLE Has 5' -> 3' DNA helic ...... e-stranded DNA-binding protein
@en
P2093
Jenny A Korhonen
Martina Gaspari
P2860
P304
P3181
P356
10.1074/JBC.M306981200
P407
P577
2003-12-05T00:00:00Z