The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
about
A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiaeIsolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformationNeurogenetics. Triumphs and challengesMolecular genetics of neurofibromatosis type 1 (NF1)Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutationsThe neurofibromatosis type I messenger RNA undergoes base-modification RNA editingInactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.RasLinking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data basesar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysisInteraction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cellsIdentification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras allelesTumor microenvironment and neurofibromatosis type I: connecting the GAPsLeukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon consensus sequence binding proteinA HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomasThe Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological DisordersAlternative splicing of the neurofibromatosis type I pre-mRNAA RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressorFrom neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formationSst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit).The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans.Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function.Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins.The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosisAntioncogenes and human cancer.Neurofibromatosis type 1 - a model for nervous system tumour formation?PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cellsRas inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosisAblation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brainNeurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytesRole of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cellsDevelopmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequenceA novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regionsNf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferaseMouse tumor model for neurofibromatosis type 1Tumour predisposition in mice heterozygous for a targeted mutation in Nf1Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of RasCotargeting MNK and MEK kinases induces the regression of NF1-mutant cancersRas oncogenes: split personalities
P2860
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P2860
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
description
1990 nî lūn-bûn
@nan
1990 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@ast
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@en
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@en-gb
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@nl
type
label
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@ast
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@en
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@en-gb
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@nl
prefLabel
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@ast
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@en
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@en-gb
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@nl
P2093
P1433
P1476
The NF1 locus encodes a protei ...... ian GAP and yeast IRA proteins
@en
P2093
P356
10.1016/0092-8674(90)90151-4
P407
P577
1990-11-16T00:00:00Z