Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function
about
Isosteviol has beneficial effects on palmitate-induced α-cell dysfunction and gene expressionPax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretionDistinct and Shared Determinants of Cardiomyocyte Contractility in Multi-Lineage Competent Ethnically Diverse Human iPSCs.The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult miceThe activation of the rat insulin gene II by BETA2 and PDX-1 in rat insulinoma cells is repressed by Pax6Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineagePax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreasPax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrainTranscriptional factors, Mafs and their biological rolesCDKAL1-related single nucleotide polymorphisms are associated with insulin resistance in a cross-sectional cohort of Greek children.Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.Interaction between Pax6 and its novel mutant in Bufo raddei StrauchPax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation MarkerDissecting Human Gene Functions Regulating Islet Development With Targeted Gene TransductionDeconstructing pancreas developmental biology.High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primateMultiple functions of Maf in the regulation of cellular development and differentiation.PAX4 promotes PDX1-induced differentiation of mesenchymal stem cells into insulin-secreting cellsGlucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion.Metabolic impact of glucagon deficiency.β-Cell differentiation and regeneration in type 1 diabetes.Taurine supplementation ameliorates glucose homeostasis, prevents insulin and glucagon hypersecretion, and controls β, α, and δ-cell masses in genetic obese mice.Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells.CCCTC-binding factor mediates effects of glucose on beta cell survival.Mapping gene regulatory circuitry of Pax6 during neurogenesis.Expression and cellular localization of the transcription factor NeuroD1 in the developing and adult rat pineal gland.CTCF mediates effect of insulin on glucagon expression.Abnormal CFTR Affects Glucagon Production by Islet α Cells in Cystic Fibrosis and Polycystic Ovarian Syndrome.
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P2860
Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Pax6 controls the expression o ...... l differentiation and function
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Pax6 controls the expression o ...... l differentiation and function
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Pax6 controls the expression o ...... l differentiation and function
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Pax6 controls the expression o ...... l differentiation and function
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Pax6 controls the expression o ...... l differentiation and function
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Pax6 controls the expression o ...... l differentiation and function
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Pax6 controls the expression o ...... l differentiation and function
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Pax6 controls the expression o ...... l differentiation and function
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Pax6 controls the expression o ...... l differentiation and function
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Pax6 controls the expression o ...... l differentiation and function
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Pax6 controls the expression o ...... l differentiation and function
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Pax6 controls the expression o ...... l differentiation and function
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P2093
P2860
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Pax6 controls the expression o ...... l differentiation and function
@en
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Aline Mamin
Audrey Guérardel
Claire Cheyssac
Eric Marthinet
Jacques Philippe
Karim Bouzakri
Liora S Katz
Yvan Gosmain
P2860
P304
P356
10.1074/JBC.M110.147215
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P577
2010-10-22T00:00:00Z