Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
about
DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegansBinding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decayThe structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complexInteractions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathwaysUpf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decayTwo mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decayFunctions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translationA competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decayUnusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay.Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardationStructures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complexNonsense-mediated mRNA decay: novel mechanistic insights and biological impactMechanism and regulation of the nonsense-mediated decay pathwayThe Supraspliceosome - A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell NucleusNonsense-mediated mRNA decay: inter-individual variability and human diseaseCoupling pre-mRNA processing to transcription on the RNA factory assembly lineThe RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complexStructural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeastNonsense-mediated mRNA decay in humans at a glanceNonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryOrganizing principles of mammalian nonsense-mediated mRNA decayThe RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNAInhibition of Nonsense-mediated mRNA Decay by the Natural Product Pateamine A through Eukaryotic Initiation Factor 4AIIIHIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.Antagonistic factors control the unproductive splicing of SC35 terminal intron.Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD).Comparison of nonsense-mediated mRNA decay efficiency in various murine tissues.Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders.Function and pathological implications of exon junction complex factor Y14The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.Multifaceted Regulation of Gene Expression by the Apoptosis- and Splicing-Associated Protein Complex and Its Components.Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.Stress-sensitive regulation of IFRD1 mRNA decay is mediated by an upstream open reading frameSplicing-dependent NMD does not require the EJC in Schizosaccharomyces pombeSelenoproteins: molecular pathways and physiological roles.The code within the code: microRNAs target coding regions.
P2860
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P248
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P2860
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Exon-junction complex componen ...... erential cofactor requirements
@ast
Exon-junction complex componen ...... erential cofactor requirements
@en
Exon-junction complex componen ...... erential cofactor requirements
@en-gb
Exon-junction complex componen ...... erential cofactor requirements
@nl
type
label
Exon-junction complex componen ...... erential cofactor requirements
@ast
Exon-junction complex componen ...... erential cofactor requirements
@en
Exon-junction complex componen ...... erential cofactor requirements
@en-gb
Exon-junction complex componen ...... erential cofactor requirements
@nl
prefLabel
Exon-junction complex componen ...... erential cofactor requirements
@ast
Exon-junction complex componen ...... erential cofactor requirements
@en
Exon-junction complex componen ...... erential cofactor requirements
@en-gb
Exon-junction complex componen ...... erential cofactor requirements
@nl
P2093
P921
P3181
P1433
P1476
Exon-junction complex componen ...... erential cofactor requirements
@en
P2093
Andreas E Kulozik
Gabriele Neu-Yilik
Joachim B Kunz
Marcelo H Viegas
Stephen Breit
P3181
P356
10.1016/J.MOLCEL.2005.08.012
P407
P577
2005-10-07T00:00:00Z