Substrate specificity and activity regulation of protein kinase MELK
about
Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complexThe WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transportersPin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effectsRegulatory motifs in Chk1Maternal embryonic leucine zipper kinase (MELK): a novel regulator in cell cycle control, embryonic development, and cancerStructural Basis for the Regulation of Maternal Embryonic Leucine Zipper KinaseThe structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activityMurine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylationPseudokinases: update on their functions and evaluation as new drug targets.Survey of phosphorylation near drug binding sites in the Protein Data Bank (PDB) and their effects.Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression.Maternal embryonic leucine zipper kinase: key kinase for stem cell phenotype in glioma and other cancers.Dueling kinases regulate cell size at division through the SAD kinase Cdr2MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis.Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathwayMurine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins.Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia.DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity.MELK-a conserved kinase: functions, signaling, cancer, and controversy.Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylationPDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activityA crucial role for the phosphorylation of STRAP at Ser(188) by MPK38 in STRAP-dependent cell death through ASK1, TGF-β, p53, and PI3K/PDK1 signaling pathways.MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cellsGenome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant.Structural insight into the mechanism of synergistic autoinhibition of SAD kinasesSolution structure of the kinase-associated domain 1 of mouse microtubule-associated protein/microtubule affinity-regulating kinase 3.Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisionsIdentification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level.MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cellsZinc finger protein ZPR9 functions as an activator of AMPK-related serine/threonine kinase MPK38/MELK involved in ASK1/TGF-β/p53 signaling pathways.Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase.Partners and post-translational modifications of nuclear laminsMELK: a potential novel therapeutic target for TNBC and other aggressive malignancies.Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals.The translation initiation factor eIF2beta is an interactor of protein phosphatase-1.Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer.
P2860
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P2860
Substrate specificity and activity regulation of protein kinase MELK
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Substrate specificity and activity regulation of protein kinase MELK
@ast
Substrate specificity and activity regulation of protein kinase MELK
@en
Substrate specificity and activity regulation of protein kinase MELK
@en-gb
Substrate specificity and activity regulation of protein kinase MELK
@nl
type
label
Substrate specificity and activity regulation of protein kinase MELK
@ast
Substrate specificity and activity regulation of protein kinase MELK
@en
Substrate specificity and activity regulation of protein kinase MELK
@en-gb
Substrate specificity and activity regulation of protein kinase MELK
@nl
prefLabel
Substrate specificity and activity regulation of protein kinase MELK
@ast
Substrate specificity and activity regulation of protein kinase MELK
@en
Substrate specificity and activity regulation of protein kinase MELK
@en-gb
Substrate specificity and activity regulation of protein kinase MELK
@nl
P2093
P2860
P50
P356
P1476
Substrate specificity and activity regulation of protein kinase MELK
@en
P2093
Hugo Ceulemans
Nick Morrice
Rita Derua
Sadia Vancauwenbergh
P2860
P304
P356
10.1074/JBC.M507274200
P407
P577
2005-12-02T00:00:00Z