Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein - Wikidata - thesis-toulmin - TriplyDB

Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein

Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein

http://www.wikidata.org/entity/Q24530025

about

ASARM peptides: PHEX-dependent and -independent regulation of serum phosphate Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP Regulation and function of the FGF23/klotho endocrine pathways Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway Excessive Osteocytic Fgf23 Secretion Contributes to Pyrophosphate Accumulation and Mineralization Defect in Hyp Mice Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1 Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice Differential regulation of PHEX expression in bone and parathyroid gland by chronic renal insufficiency and 1,25-dihydroxyvitamin D3 PHEX mimetic (SPR4-peptide) corrects and improves HYP and wild type mice energy-metabolism Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships The use of Fluorescence Resonance Energy Transfer (FRET) peptides for measurement of clinically important proteolytic enzymes.Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin.Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator.Expression and distribution of SIBLING proteins in the predentin/dentin and mandible of hyp mice.Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif The wrickkened pathways of FGF23, MEPE and PHEX.Phosphate: known and potential roles during development and regeneration of teeth and supporting structures.Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled."Phosphatonins" and the regulation of phosphorus homeostasis.Emerging role of a phosphatonin in mineral homeostasis and its derangements.Endocrine functions of bone in mineral metabolism regulation.Studies of the DMP1 57-kDa functional domain both in vivo and in vitro.Novel regulators of Fgf23 expression and mineralization in Hyp bone Biological activity of FGF-23 fragments.Increased cathepsin D release by Hyp mouse osteoblast cells.MEPE has the properties of an osteoblastic phosphatonin and minhibin.Evidence for the proteolytic processing of dentin matrix protein 1. Identification and characterization of processed fragments and cleavage sites.Profile of asfotase alfa in the treatment of hypophosphatasia: design, development, and place in therapy

P2860

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P2860

Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein

http://www.wikidata.org/entity/Q24530025

description

2003 nî lūn-bûn

@nan

2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2003年の論文

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2003年論文

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2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Human recombinant endopeptidas ...... racellular phosphoglycoprotein

@ast

Human recombinant endopeptidas ...... racellular phosphoglycoprotein

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Human recombinant endopeptidas ...... racellular phosphoglycoprotein

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Human recombinant endopeptidas ...... racellular phosphoglycoprotein

@nl

type

label

Human recombinant endopeptidas ...... racellular phosphoglycoprotein

@ast

Human recombinant endopeptidas ...... racellular phosphoglycoprotein

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Human recombinant endopeptidas ...... racellular phosphoglycoprotein

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Human recombinant endopeptidas ...... racellular phosphoglycoprotein

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prefLabel

Human recombinant endopeptidas ...... racellular phosphoglycoprotein

@ast

Human recombinant endopeptidas ...... racellular phosphoglycoprotein

@en

Human recombinant endopeptidas ...... racellular phosphoglycoprotein

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Human recombinant endopeptidas ...... racellular phosphoglycoprotein

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P1433

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P2860

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P304

Q24530025-24F1D00F-F772-42D3-A4E3-01612792A103

P31

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P3181

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P932

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P3181

P356

P1433

Biochemical Journal

P1476

Human recombinant endopeptidas ...... racellular phosphoglycoprotein

@en

P2093

Adriana K Carmona

http://www.w3.org/2001/XMLSchema#string

Constance Couture

http://www.w3.org/2001/XMLSchema#string

Guy Boileau

http://www.w3.org/2001/XMLSchema#string

Izaura Y Hirata

http://www.w3.org/2001/XMLSchema#string

Luiz Juliano

http://www.w3.org/2001/XMLSchema#string

Marcelo Campos

http://www.w3.org/2001/XMLSchema#string

Maria A Juliano

http://www.w3.org/2001/XMLSchema#string

Philippe Crine

http://www.w3.org/2001/XMLSchema#string

Thomas P Loisel

http://www.w3.org/2001/XMLSchema#string

P2860

MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia

FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate

Expression and cloning of the human X-linked hypophosphatemia gene cDNA

Cloning of human PEX cDNA. Expression, subcellular localization, and endopeptidase activity

Organization and chromosomal localization of the human ECEL1 (XCE) gene encoding a zinc metallopeptidase involved in the nervous control of respiration

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon

On the size of the active site in proteases. I. Papain

X-linked hypophosphataemia: a homologous disorder in humans and mice

P304

271-9

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P31

scholarly article

P3181

4944779

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P356

10.1042/BJ20030287

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P407

P433

Pt 1

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P478

373

http://www.w3.org/2001/XMLSchema#string

P577

2003-07-01T00:00:00Z

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P698

12678920

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P921

extracellular matrix

P932

1223479

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