Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
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Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cellsInhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agentTargeting protein serine/threonine phosphatases for drug developmentPost-translational generation of constitutively active cores from larger phosphatases in the malaria parasite, Plasmodium falciparum: implications for proteomicsThe cyclophilinsDirect and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksStructure of cyclophilin fromLeishmania donovaniat 1.97 Å resolutionStructure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal CoordinatesStructural basis for the cyclophilin A binding affinity and immunosuppressive potency ofE-ISA247 (voclosporin)The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of CalcineurinStructure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomidevSDC: a method to improve early recognition in virtual screening when limited experimental resources are availableRole of calcineurin and actin dynamics in regulated secretion of microneme proteins in Plasmodium falciparum merozoites during erythrocyte invasionProtein stability: a crystallographer's perspectiveA reassessment of the inhibitory capacity of human FKBP38 on calcineurinCalcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl IsomerizationCharacterization of the FKBP12-Encoding Genes in Aspergillus fumigatusConformational Heterogeneity of Cyclosporin A in Cyclophilin 18 BindingA central role for calcineurin in protein misfolding neurodegenerative diseases.Fine tuning the inhibition profile of cyclosporine A by derivatization of the MeBmt residue.A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex.Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo.Calcineurin A versus NS5A-TP2/HD domain containing 2: a case study of site-directed low-frequency random mutagenesis for dissecting target specificity of peptide aptamersIn vitro extinction learning in Hermissenda: involvement of conditioned inhibition moleculesTherapeutic effects of astragaloside IV on myocardial injuries: multi-target identification and network analysis.The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients.Calcineurin inhibition blocks within-, but not between-session fear extinction in miceViewing serine/threonine protein phosphatases through the eyes of drug designersNMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound statesBinding of the cyclophilin 40 ortholog SQUINT to Hsp90 protein is required for SQUINT function in Arabidopsis.Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infectionCrystallization and preliminary crystallographic study of a trypsin-resistant catalytic domain of human calcineurin.Cyclosporin A impairs the secretion and activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat).A novel class of dual-family immunophilins.Cooperative autoinhibition and multi-level activation mechanisms of calcineurinSPLINTS: small-molecule protein ligand interface stabilizers.Correlation of naturally occurring HIV-1 resistance to DEB025 with capsid amino acid polymorphismsProteomics identification of cyclophilin a as a potential prognostic factor and therapeutic target in endometrial carcinomaCalcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization.Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation
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P2860
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Crystal structure of calcineur ...... of immunophilin-drug complexes
@ast
Crystal structure of calcineur ...... of immunophilin-drug complexes
@en
Crystal structure of calcineur ...... of immunophilin-drug complexes
@en-gb
Crystal structure of calcineur ...... of immunophilin-drug complexes
@nl
type
label
Crystal structure of calcineur ...... of immunophilin-drug complexes
@ast
Crystal structure of calcineur ...... of immunophilin-drug complexes
@en
Crystal structure of calcineur ...... of immunophilin-drug complexes
@en-gb
Crystal structure of calcineur ...... of immunophilin-drug complexes
@nl
prefLabel
Crystal structure of calcineur ...... of immunophilin-drug complexes
@ast
Crystal structure of calcineur ...... of immunophilin-drug complexes
@en
Crystal structure of calcineur ...... of immunophilin-drug complexes
@en-gb
Crystal structure of calcineur ...... of immunophilin-drug complexes
@nl
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Crystal structure of calcineur ...... of immunophilin-drug complexes
@en
P2093
Angelo Mondragon
Hwa-Young Kim
Yingdong Zhao
Yudong Liu
P2860
P304
P3181
P356
10.1073/PNAS.192206699
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P50
P577
2002-09-17T00:00:00Z