Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
about
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agentPost-translational generation of constitutively active cores from larger phosphatases in the malaria parasite, Plasmodium falciparum: implications for proteomicsThe cyclophilinsRecent Advances Toward the Discovery of Drug-Like Peptides De novoCalcineurin inhibition and new-onset diabetes mellitus after transplantationThe Role of Medical Structural Genomics in Discovering New Drugs for Infectious DiseasesStructure of cyclophilin fromLeishmania donovaniat 1.97 Å resolutionThe structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3.Structure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal CoordinatesStructural basis for the cyclophilin A binding affinity and immunosuppressive potency ofE-ISA247 (voclosporin)The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of CalcineurinA reassessment of the inhibitory capacity of human FKBP38 on calcineurinDevelopment of a Fluorescent Quenching Based High Throughput Assay to Screen for Calcineurin InhibitorsCalcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl IsomerizationCyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinomaCharacterization of the FKBP12-Encoding Genes in Aspergillus fumigatusConformational Heterogeneity of Cyclosporin A in Cyclophilin 18 BindingMitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivationA central role for calcineurin in protein misfolding neurodegenerative diseases.Fine tuning the inhibition profile of cyclosporine A by derivatization of the MeBmt residue.A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex.Structure collisions between interacting proteinsIdentification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo.Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library.Therapeutic effects of astragaloside IV on myocardial injuries: multi-target identification and network analysis.Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures.Viewing serine/threonine protein phosphatases through the eyes of drug designersStructural basis for protein phosphatase 1 regulation and specificityCyclophilin nomenclature problems, or, 'a visit from the sequence police'.Crystallization and preliminary crystallographic study of a trypsin-resistant catalytic domain of human calcineurin.A novel class of dual-family immunophilins.Cooperative autoinhibition and multi-level activation mechanisms of calcineurinSPLINTS: small-molecule protein ligand interface stabilizers.Correlation of naturally occurring HIV-1 resistance to DEB025 with capsid amino acid polymorphismsProteomics identification of cyclophilin a as a potential prognostic factor and therapeutic target in endometrial carcinomaCalmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activationRecent progress on the structure of Ser/Thr protein phosphatases.Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury.Quercetin targets the interaction of calcineurin with LxVP-type motifs in immunosuppression.Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
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P248
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P2860
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
@ast
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
@en
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
@nl
type
label
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
@ast
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
@en
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
@nl
prefLabel
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
@ast
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
@en
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
@nl
P2860
P921
P3181
P356
P1476
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
@en
P2093
Stephen C Harrison
P2860
P304
P3181
P356
10.1073/PNAS.212504399
P407
P577
2002-10-15T00:00:00Z