Role for the adaptor protein Grb10 in the activation of Akt - Wikidata - thesis-toulmin - TriplyDB

Role for the adaptor protein Grb10 in the activation of Akt

Role for the adaptor protein Grb10 in the activation of Akt

http://www.wikidata.org/entity/Q24537512

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Phosphorylation of grb10 regulates its interaction with 14-3-3 Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancer Altered expression and deletion of RMO1 in osteosarcoma Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling Tissue-specific regulation and function of Grb10 during growth and neuronal commitment.The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.Lipid rafts are required for Kit survival and proliferation signals Grb10 and Grb14: enigmatic regulators of insulin action--and more?HuR inhibits apoptosis by amplifying Akt signaling through a positive feedback loop.Adapter protein connections: the MRL and Grb7 protein families.Stem cell factor expression, mast cells and inflammation in asthma.Backbone nuclear relaxation characteristics and calorimetric investigation of the human Grb7-SH2/erbB2 peptide complex Update on imatinib for gastrointestinal stromal tumors: duration of treatment.Grb10 is a dual regulator of receptor tyrosine kinase signaling.Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.Grb10 is involved in BCR-ABL-positive leukemia in mice.FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia Akt2 interacts with Snail1 in the E-cadherin promoter.c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways.Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor.Molecular mechanisms of OLIG2 transcription factor in brain cancer.Direct interaction between Kit and the interleukin-7 receptor.F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC: a novel mode of kinase inhibitor resistance.Rapid identification of dysregulated genes in cutaneous malignant melanoma metastases using cDNA technology.Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.Imprinted survival genes preclude loss of heterozygosity of chromosome 7 in cancer cells.Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation.Interaction of other adapter proteins with p-KIT Connexin 43 C-terminus directly inhibits the hyperphosphorylation of Akt/ERK through protein-protein interactions in glioblastoma

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Role for the adaptor protein Grb10 in the activation of Akt

http://www.wikidata.org/entity/Q24537512

description

2002 nî lūn-bûn

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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2002 թվականի փետրվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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name

Role for the adaptor protein Grb10 in the activation of Akt

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Role for the adaptor protein Grb10 in the activation of Akt

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Role for the adaptor protein Grb10 in the activation of Akt

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Role for the adaptor protein Grb10 in the activation of Akt

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Role for the adaptor protein Grb10 in the activation of Akt

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Role for the adaptor protein Grb10 in the activation of Akt

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Role for the adaptor protein Grb10 in the activation of Akt

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Role for the adaptor protein Grb10 in the activation of Akt

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Role for the adaptor protein Grb10 in the activation of Akt

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Role for the adaptor protein Grb10 in the activation of Akt

@en

Role for the adaptor protein Grb10 in the activation of Akt

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Role for the adaptor protein Grb10 in the activation of Akt

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MCB.22.4.979-991.2002

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Molecular and Cellular Biology

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Role for the adaptor protein Grb10 in the activation of Akt

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P2093

Christian Peschel

http://www.w3.org/2001/XMLSchema#string

Justus Duyster

http://www.w3.org/2001/XMLSchema#string

Petra Seipel

http://www.w3.org/2001/XMLSchema#string

Susanne Urschel

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Thomas Jahn

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A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis

Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner

Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family

Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool

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979-991

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scholarly article

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4524971

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10.1128/MCB.22.4.979-991.2002

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